Bélec L, Testa J, Vohito M D, Gresenguet G, Martin M I, Tabo A, Di Costanzo B, Georges A J
Institut Pasteur de Bangui, République centrafricaine.
Bull Soc Pathol Exot Filiales. 1989;82(3):297-307.
To describe and evaluate the frequency of neurological and psychiatric manifestations in African patients with AIDS, 93 in patients at the National Hospital Center, Bangui, were chosen according to the WHO clinical definition of AIDS and were confirmed to be HIV-1 positive (92/93) or HIV-2 positive (1/93) by Western blot. Patients were given both neurologic and psychiatric examinations. Cortico-spinal fluid (CSF) analysis was performed in case of neuro-psychiatric signs. 11 patients presented neurologic symptoms: 5 had focal processes associated in 2 cases with deep coma, 4 had cryptococcal meningitidis, 1 demonstrated peripheral facial paralysis, and there was one case of abnormal movement, choréo-athétotic type. 4 patients presented frank psychiatric symptoms (3 dementia syndromes, one of whom was HIV-2 positive, and 1 case of hallucinatory psychosis). CSF analysis was only helpful in the etiologic diagnosis of cryptococcal infection. The mortality rate in these 15 patients was 60% during the 2-month study. In this series, neurologic and/or psychiatric symptoms were detected in 16 (15/93)% of African patients with AIDS.
为描述和评估非洲艾滋病患者神经和精神症状的发生率，按照世界卫生组织艾滋病临床定义，从班吉国立医院中心选取了93例患者，并通过免疫印迹法确认他们为HIV-1阳性（92/93）或HIV-2阳性（1/93）。对患者进行了神经和精神检查。出现神经精神症状时进行了脑脊液（CSF）分析。11例患者出现神经症状：5例有局灶性病变，其中2例伴有深度昏迷；4例患有隐球菌性脑膜炎；1例表现为周围性面瘫；还有1例为异常运动，呈舞蹈徐动型。4例患者出现明显的精神症状（3例为痴呆综合征，其中1例为HIV-2阳性，1例为幻觉性精神病）。脑脊液分析仅有助于隐球菌感染的病因诊断。在为期2个月的研究中，这15例患者的死亡率为60%。在该系列研究中，16（15/93）%的非洲艾滋病患者检测到神经和/或精神症状。
