发育异常痣与普通黑素细胞痣分子差异的新见解——强调角质形成细胞与黑素细胞的关系
New Insights into the Molecular Distinction of Dysplastic Nevi and Common Melanocytic Nevi-Highlighting the Keratinocyte-Melanocyte Relationship.
作者信息
Eliades Philip, Tsao Hensin
机构信息
Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; Tufts University School of Medicine, Boston, Massachusetts, USA.
Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
J Invest Dermatol. 2016 Oct;136(10):1933-1935. doi: 10.1016/j.jid.2016.01.008.
Mitsui et al. approach the problem of differentiating dysplastic nevi from common melanocytic nevi through a molecular lens. Whereas most of the literature on this topic shines the spotlight toward melanocytes, the focus of this paper is shifted to the tumor microenvironment. Using microarrays, reverse transcriptase-PCR, and immunohistochemistry, their results emphasize the role of keratinocyte dysplasia within dysplastic nevi.
三井等人通过分子视角来探讨区分发育异常痣与普通黑素细胞痣的问题。尽管关于该主题的大多数文献都将焦点投向黑素细胞，但本文的重点转向了肿瘤微环境。通过使用微阵列、逆转录聚合酶链反应和免疫组织化学，他们的研究结果强调了发育异常痣中角质形成细胞发育异常的作用。
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