恶性黑色素瘤的一级和二级化学预防
Primary and Secondary Chemoprevention of Malignant Melanoma.
作者信息
Mounessa Jessica, Buntinx-Krieg Talayesa, Qin Rosie, Dunnick Cory A, Dellavalle Robert P
机构信息
Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, NY, 11794, USA.
Department of Dermatology, University of Colorado Hospital, 1665 Aurora Ct, Aurora, CO, 80045, USA.
出版信息
Am J Clin Dermatol. 2016 Dec;17(6):625-634. doi: 10.1007/s40257-016-0221-5.
The incidence of malignant melanoma (MM) continues to rise in the United States. While sun protection and full body skin examinations remain the mainstay of preventative care, chemoprevention of the deadly disease has become an increasingly popular field of study. In this focused review, we discuss current findings and analyze the risks and benefits of various agents investigated for the primary and secondary chemoprevention of MM. Such agents include topical retinoids, vitamins, and supplements, Polypodium leucotomas extracts, non-steroidal anti-inflammatory agents (NSAIDs), statins, sunscreens, and field therapy with topical imiquimod for primary and secondary chemoprevention. We further identify a need for expanded high quality human research on the topic.
在美国，恶性黑色素瘤（MM）的发病率持续上升。虽然防晒和全身皮肤检查仍是预防保健的主要手段，但对这种致命疾病的化学预防已成为一个越来越热门的研究领域。在这篇重点综述中，我们讨论了当前的研究结果，并分析了为MM的一级和二级化学预防而研究的各种药物的风险和益处。这些药物包括局部用维甲酸、维生素和补充剂、白鬼笔提取物、非甾体抗炎药（NSAIDs）、他汀类药物、防晒霜，以及用于一级和二级化学预防的局部用咪喹莫特的病灶治疗。我们进一步指出，需要就该主题开展更多高质量的人体研究。
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