Doctoral Program of Biosciences, School of Engineering, Universidad de La Sabana, Chía 140013, Cundinamarca, Colombia.
Bioprospecting Research Group, School of Engineering, Universidad de La Sabana, Chía 140013, Cundinamarca, Colombia.
Molecules. 2020 Jul 15;25(14):3221. doi: 10.3390/molecules25143221.
Sun overexposure is associated with the development of diseases that primarily affect the skin, which can lead to skin cancer. Among the main measures of photoprotection is the use of sunscreens. However, there is currently concern about the reported harmful effects to both humans and the environment due to several of the sunscreen ingredients available on the market. For this reason, the search for and development of new agents with photoprotective properties is required. In searching for these metabolites, researchers have turned their attention to microbial sources, especially the microbiota in unusual hostile environments. Among the diverse microorganisms available in nature, Actinobacteria and specifically , have been shown to be a source of metabolites with various biological activities of interest, such as antimicrobial, antitumor and immunomodulator activities. Herein, we present the results of a systematic review of the literature in which isolates were studied as a source of compounds with photoprotective properties. A meta-analysis of the structure-property and structure-activity relationships of those metabolites identified in the qualitative analysis phase was also carried out. These findings indicate that are a source of metabolites with potential applications in the development of new, safe and more eco-friendly sunscreens.
过度暴露在阳光下与皮肤疾病的发展有关，这些疾病主要影响皮肤，可能导致皮肤癌。光保护的主要措施之一是使用防晒霜。然而，由于市场上现有的几种防晒霜成分，人们目前担心这些成分对人类和环境都有有害影响。因此，需要寻找和开发具有光保护特性的新制剂。在寻找这些代谢物的过程中，研究人员将注意力转向了微生物来源，特别是在异常恶劣环境中的微生物群。在自然界中存在的各种微生物中，放线菌，特别是 ，已被证明是具有各种生物活性的代谢物的来源，如抗菌、抗肿瘤和免疫调节剂活性。在此，我们呈现了对文献进行系统回顾的结果，其中研究了 作为具有光保护特性的化合物的来源。还对定性分析阶段中鉴定的那些代谢物的结构-性质和结构-活性关系进行了荟萃分析。这些研究结果表明， 是具有潜在应用于开发新的、安全和更环保的防晒霜的代谢物的来源。
