放射性同位素研究在戈谢病监测及其治疗中的应用。

Radioisotope studies in monitoring of Gaucher's disease and its treatment.

作者信息

Dokal I S, Deenmamode M, Lewis S M

机构信息

Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

出版信息

Clin Lab Haematol. 1989;11(2):91-6. doi: 10.1111/j.1365-2257.1989.tb00188.x.

DOI:10.1111/j.1365-2257.1989.tb00188.x

PMID:2766675

Abstract

Radioisotope studies (blood volume, spleen function, and ferrokinetics) were performed in seven patients with chronic (type 1) Gaucher's disease. Interestingly, the 52Fe scans and spleen histology demonstrated extramedullary haemopoiesis in the liver and spleen. Radioisotope measurements (red cell volume, plasma volume, red cell pool, damaged cell clearance, spleen blood flow, 59Fe clearance, red cell utilization and 52Fe scans) provide methods for accurate measurement of the bone marrow and spleen function, thereby enabling prediction of the most suitable time for splenectomy, in the treatment of patients with Gaucher's disease.

摘要

对7例慢性（1型）戈谢病患者进行了放射性同位素研究（血容量、脾功能和铁动力学）。有趣的是，52Fe扫描和脾组织学显示肝脏和脾脏存在髓外造血。放射性同位素测量（红细胞体积、血浆体积、红细胞池、受损细胞清除率、脾血流量、59Fe清除率、红细胞利用率和52Fe扫描）提供了准确测量骨髓和脾功能的方法，从而能够预测在戈谢病患者治疗中脾切除术的最合适时机。