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纺织有机电化学晶体管作为可穿戴生物传感器的平台。

Textile Organic Electrochemical Transistors as a Platform for Wearable Biosensors.

作者信息

Gualandi I, Marzocchi M, Achilli A, Cavedale D, Bonfiglio A, Fraboni B

机构信息

Dipartimento di Fisica e Astronomia, Università di Bologna, Viale Berti Pichat 6/2, 40127 Bologna, Italy.

Dipartimento di Ingegneria Elettrica ed Elettronica, Università di Cagliari, Piazza D'Armi, 09123 Cagliari, Italy.

出版信息

Sci Rep. 2016 Sep 26;6:33637. doi: 10.1038/srep33637.

Abstract

The development of wearable chemical sensors is receiving a great deal of attention in view of non-invasive and continuous monitoring of physiological parameters in healthcare applications. This paper describes the development of a fully textile, wearable chemical sensor based on an organic electrochemical transistor (OECT) entirely made of conductive polymer (PEDOT:PSS). The active polymer patterns are deposited into the fabric by screen printing processes, thus allowing the device to actually "disappear" into it. We demonstrate the reliability of the proposed textile OECTs as a platform for developing chemical sensors capable to detect in real-time various redox active molecules (adrenaline, dopamine and ascorbic acid), by assessing their performance in two different experimental contexts: i) ideal operation conditions (i.e. totally dipped in an electrolyte solution); ii) real-life operation conditions (i.e. by sequentially adding few drops of electrolyte solution onto only one side of the textile sensor). The OECTs response has also been measured in artificial sweat, assessing how these sensors can be reliably used for the detection of biomarkers in body fluids. Finally, the very low operating potentials (<1 V) and absorbed power (~10W) make the here described textile OECTs very appealing for portable and wearable applications.

摘要

鉴于可穿戴化学传感器在医疗保健应用中对生理参数进行无创和连续监测,其发展受到了广泛关注。本文描述了一种完全基于有机电化学晶体管(OECT)的全纺织可穿戴化学传感器的开发,该晶体管完全由导电聚合物(PEDOT:PSS)制成。活性聚合物图案通过丝网印刷工艺沉积到织物中,从而使该装置能够真正“融入”其中。我们通过在两种不同的实验环境中评估其性能,证明了所提出的纺织OECT作为开发能够实时检测各种氧化还原活性分子(肾上腺素、多巴胺和抗坏血酸)的化学传感器平台的可靠性:i)理想操作条件(即完全浸入电解质溶液中);ii)实际操作条件(即通过在纺织传感器的一侧依次滴加几滴电解质溶液)。还在人工汗液中测量了OECT的响应,评估了这些传感器如何可靠地用于检测体液中的生物标志物。最后,非常低的工作电位(<1 V)和吸收功率(~10W)使得本文所述的纺织OECT对便携式和可穿戴应用非常有吸引力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4fd/5035988/ea9ba7c27982/srep33637-f1.jpg

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