Ferguson A C, Wong F W
Department of Paediatrics, University of British Columbia, Vancouver, Canada.
Chest. 1989 Nov;96(5):988-91. doi: 10.1378/chest.96.5.988.
Bronchial responsiveness assessed by histamine bronchial challenge testing in 22 children with chronic stable asthma was compared with the number of inflammatory cells per milliliter of broncholavage fluid obtained by fiberoptic bronchoscopy. Hyperresponsiveness was closely correlated with increased counts of eosinophils and macrophages and with the ratio of eosinophils to macrophages. There was no correlation of neutrophil or lymphocyte counts with bronchial hyperresponsiveness and none of the cell types was correlated with airway obstruction. Our findings support the hypotheses that macrophages may be important in the development of bronchial hyperresponsiveness in children with asthma and that they may modulate bronchial responsiveness both directly and by recruitment of eosinophils.
通过组胺支气管激发试验评估了22名慢性稳定型哮喘儿童的支气管反应性，并与通过纤维支气管镜获得的每毫升支气管灌洗液中的炎症细胞数量进行了比较。高反应性与嗜酸性粒细胞和巨噬细胞数量增加以及嗜酸性粒细胞与巨噬细胞的比例密切相关。中性粒细胞或淋巴细胞计数与支气管高反应性无相关性，且任何一种细胞类型均与气道阻塞无相关性。我们的研究结果支持以下假设：巨噬细胞可能在哮喘儿童支气管高反应性的发展中起重要作用，并且它们可能直接或通过募集嗜酸性粒细胞来调节支气管反应性。
