Grant Jon E, Redden Sarah A, Leppink Eric W, Chamberlain Samuel R
Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, IL.
Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, IL.
Compr Psychiatry. 2017 Jan;72:1-5. doi: 10.1016/j.comppsych.2016.09.005. Epub 2016 Sep 16.
Trichotillomania appears to be a fairly common disorder, with high rates of co-occurring anxiety disorders. Many individuals with trichotillomania also report that pulling worsens during periods of increased anxiety. Even with these clinical links to anxiety, little research has explored whether trichotillomania with co-occurring anxiety is a meaningful subtype.
One hundred sixty-five adults with trichotillomania were examined on a variety of clinical measures including symptom severity, functioning, and comorbidity. Participants also underwent cognitive testing assessing motor inhibition and cognitive flexibility. Clinical features and cognitive functioning were compared between those with current co-occurring anxiety disorders (i.e. social anxiety, generalized anxiety disorder, panic disorder, and anxiety disorder NOS) (n=38) and those with no anxiety disorder (n=127).
Participants with trichotillomania and co-occurring anxiety reported significantly worse hair pulling symptoms, were more likely to have co-occurring depression, and were more likely to have a first-degree relative with obsessive compulsive disorder. Those with anxiety disorders also exhibited significantly worse motor inhibitory performance on a task of motor inhibition (stop-signal task).
This study suggests that anxiety disorders affect the clinical presentation of hair pulling behavior. Further research is needed to validate our findings and to consider whether treatments should be specially tailored differently for adults with trichotillomania who have co-occurring anxiety disorders, or more pronounced cognitive impairment.
拔毛癖似乎是一种相当常见的疾病,同时患有焦虑症的比例很高。许多拔毛癖患者还报告称,在焦虑加剧期间,拔毛行为会恶化。尽管存在这些与焦虑的临床关联,但很少有研究探讨同时患有焦虑症的拔毛癖是否是一种有意义的亚型。
对165名患有拔毛癖的成年人进行了多种临床测量,包括症状严重程度、功能状况和共病情况。参与者还接受了评估运动抑制和认知灵活性的认知测试。比较了当前同时患有焦虑症(即社交焦虑症、广泛性焦虑症、恐慌症和未特定的焦虑症)的患者(n = 38)和没有焦虑症的患者(n = 127)的临床特征和认知功能。
患有拔毛癖且同时患有焦虑症的参与者报告称,拔毛症状明显更严重,更有可能同时患有抑郁症,并且更有可能有强迫症的一级亲属。患有焦虑症的患者在运动抑制任务(停止信号任务)中的运动抑制表现也明显更差。
这项研究表明,焦虑症会影响拔毛行为的临床表现。需要进一步的研究来验证我们的发现,并考虑对于同时患有焦虑症或认知障碍更明显的成年拔毛癖患者,治疗是否应进行特殊的针对性调整。