Qu Lu Lu, Liu Ying-Ya, Liu Ming-Kai, Yang Guo-Hai, Li Da-Wei, Li Hai-Tao
School of Chemistry and Chemical Engineering, Jiangsu Normal University , Xuzhou, Jiangsu 221116, P. R. China.
Shanghai Key Laboratory of Functional Materials Chemistry & College of Chemistry and Molecular Engineering, East China University of Science and Technology , Shanghai 200237, P. R. China.
ACS Appl Mater Interfaces. 2016 Oct 19;8(41):28180-28186. doi: 10.1021/acsami.6b08790. Epub 2016 Oct 5.
The increasing pollution of aquatic environments by antibiotics makes it necessary to develop efficient enrichment and sensitive detection methods for environmental antibiotics monitoring. In this work, silver nanoparticles and carbon nanotube-intercalated graphene oxide laminar membranes (Ag NPs/CNT-GO membranes) were successfully prepared for enrichment and surface-enhanced Raman scattering (SERS) detection of antibiotics. The prepared Ag NPs/CNT-GO membranes exhibited a high enrichment ability because of the π-π stacking and electrostatic interactions of GO toward antibiotic molecules, which enhanced the sensitivity of SERS measurements and enabled the antibiotics to be determined at sub-nM concentrations. In addition, the nanochannels created by the intercalation of CNTs into GO layers resulted in an 8-fold enhancement in the water permeance of Ag NPs/CNT-GO membranes compared to that of pure GO membranes. More importantly, the Ag NPs/CNT-GO membranes exhibited high reproducibility and long-term stability. The spot-to-spot variation in SERS intensity was less than 15%, and the SERS performance was maintained for at least 70 days. The Ag NPs/CNT-GO membranes were also used for SERS detection of antibiotics in real samples; the results showed that the characteristic peaks of antibiotics were obviously recognizable. Thus, the sensitive SERS detection of antibiotics based on Ag NPs/CNT-GO offers great potential for practical applications in environmental analysis.
抗生素对水生环境的污染日益严重，因此有必要开发高效的富集方法和灵敏的检测方法来监测环境中的抗生素。在本研究中，成功制备了银纳米颗粒和碳纳米管插层氧化石墨烯层状膜（Ag NPs/CNT-GO膜）用于抗生素的富集和表面增强拉曼散射（SERS）检测。所制备的Ag NPs/CNT-GO膜表现出高富集能力，这是由于氧化石墨烯与抗生素分子之间的π-π堆积和静电相互作用，增强了SERS测量的灵敏度，使得能够在亚纳摩尔浓度下测定抗生素。此外，碳纳米管插入氧化石墨烯层所形成的纳米通道使Ag NPs/CNT-GO膜的水渗透通量比纯氧化石墨烯膜提高了8倍。更重要的是，Ag NPs/CNT-GO膜具有高重现性和长期稳定性。SERS强度的点与点之间的变化小于15%，并且SERS性能至少保持70天。Ag NPs/CNT-GO膜还用于实际样品中抗生素的SERS检测；结果表明，抗生素的特征峰明显可辨。因此，基于Ag NPs/CNT-GO的抗生素灵敏SERS检测在环境分析的实际应用中具有巨大潜力。
