携带mcr-1耐黏菌素基因的医院污水来源的克吕沃氏菌菌株。
Kluyvera ascorbata Strain from Hospital Sewage Carrying the mcr-1 Colistin Resistance Gene.
作者信息
Zhao Feifei, Zong Zhiyong
机构信息
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
出版信息
Antimicrob Agents Chemother. 2016 Nov 21;60(12):7498-7501. doi: 10.1128/AAC.01165-16. Print 2016 Dec.
Abstract
The newly identified plasmid-borne colistin resistance gene mcr-1 was found in a Kluyvera ascorbata isolate from hospital sewage in China. mcr-1 was carried by a 57-kb self-transmissible IncI2 plasmid. Unlike in a previous report, mcr-1 was not associated with ISApl1 and was inserted into a gene encoding a putative membrane protein by an unknown mechanism. This study highlights that mcr-1 has spread to multiple bacterial species.
摘要
在中国医院污水分离出的一株抗坏血酸克吕沃尔氏菌中发现了新鉴定的质粒介导的黏菌素耐药基因mcr-1。mcr-1由一个57 kb的可自我传递的IncI2质粒携带。与之前的报道不同，mcr-1与ISApl1无关，并且通过未知机制插入到一个编码假定膜蛋白的基因中。这项研究强调了mcr-1已经传播到多种细菌物种。
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