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本文引用的文献

1
Dissemination of the mcr-1 colistin resistance gene.mcr-1 黏菌素耐药基因的传播
Lancet Infect Dis. 2016 Mar;16(3):289-90. doi: 10.1016/S1473-3099(16)00067-0.
2
Carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1.同时产NDM-9和MCR-1的耐碳青霉烯类和耐黏菌素大肠杆菌
Lancet Infect Dis. 2016 Mar;16(3):288-9. doi: 10.1016/S1473-3099(16)00057-8. Epub 2016 Feb 1.
3
Colistin-resistant Escherichia coli harbouring mcr-1 isolated from food animals in Hanoi, Vietnam.从越南河内食用动物中分离出的携带mcr-1基因的耐黏菌素大肠杆菌。
Lancet Infect Dis. 2016 Mar;16(3):286-7. doi: 10.1016/S1473-3099(16)00014-1. Epub 2016 Jan 8.
4
Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid.耐多药质粒携带的黏菌素耐药基因mcr-1
Lancet Infect Dis. 2016 Mar;16(3):283-4. doi: 10.1016/S1473-3099(16)00012-8. Epub 2016 Jan 8.
5
Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli.大肠杆菌临床分离株中质粒介导的碳青霉烯类和黏菌素耐药性
Lancet Infect Dis. 2016 Mar;16(3):281. doi: 10.1016/S1473-3099(16)00006-2. Epub 2016 Jan 8.
6
Investigation of a plasmid genome database for colistin-resistance gene mcr-1.针对黏菌素耐药基因mcr-1的质粒基因组数据库研究。
Lancet Infect Dis. 2016 Mar;16(3):284-5. doi: 10.1016/S1473-3099(16)00008-6. Epub 2016 Jan 8.
7
Co-occurrence of extended spectrum β lactamase and MCR-1 encoding genes on plasmids.质粒上超广谱β-内酰胺酶与MCR-1编码基因的共现。
Lancet Infect Dis. 2016 Mar;16(3):281-2. doi: 10.1016/S1473-3099(16)00007-4. Epub 2016 Jan 8.
8
Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany.德国产超广谱β-内酰胺酶和碳青霉烯酶的革兰氏阴性菌中的黏菌素耐药基因mcr-1
Lancet Infect Dis. 2016 Mar;16(3):282-3. doi: 10.1016/S1473-3099(16)00009-8. Epub 2016 Jan 8.
9
Colistin resistance gene mcr-1 and pHNSHP45 plasmid in human isolates of Escherichia coli and Klebsiella pneumoniae.人源大肠杆菌和肺炎克雷伯菌分离株中的黏菌素耐药基因mcr-1和pHNSHP45质粒
Lancet Infect Dis. 2016 Mar;16(3):285-6. doi: 10.1016/S1473-3099(16)00010-4. Epub 2016 Jan 8.
10
Dissemination of the mcr-1 colistin resistance gene.mcr-1 黏菌素耐药基因的传播
Lancet Infect Dis. 2016 Feb;16(2):144-5. doi: 10.1016/S1473-3099(15)00538-1. Epub 2015 Dec 18.

携带mcr-1耐黏菌素基因的医院污水来源的克吕沃氏菌菌株。

Kluyvera ascorbata Strain from Hospital Sewage Carrying the mcr-1 Colistin Resistance Gene.

作者信息

Zhao Feifei, Zong Zhiyong

机构信息

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China

出版信息

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7498-7501. doi: 10.1128/AAC.01165-16. Print 2016 Dec.

DOI:10.1128/AAC.01165-16
PMID:27671069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5119035/
Abstract

The newly identified plasmid-borne colistin resistance gene mcr-1 was found in a Kluyvera ascorbata isolate from hospital sewage in China. mcr-1 was carried by a 57-kb self-transmissible IncI2 plasmid. Unlike in a previous report, mcr-1 was not associated with ISApl1 and was inserted into a gene encoding a putative membrane protein by an unknown mechanism. This study highlights that mcr-1 has spread to multiple bacterial species.

摘要

在中国医院污水分离出的一株抗坏血酸克吕沃尔氏菌中发现了新鉴定的质粒介导的黏菌素耐药基因mcr-1。mcr-1由一个57 kb的可自我传递的IncI2质粒携带。与之前的报道不同，mcr-1与ISApl1无关，并且通过未知机制插入到一个编码假定膜蛋白的基因中。这项研究强调了mcr-1已经传播到多种细菌物种。