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Kluyvera ascorbata Strain from Hospital Sewage Carrying the mcr-1 Colistin Resistance Gene.携带mcr-1耐黏菌素基因的医院污水来源的克吕沃氏菌菌株。
Antimicrob Agents Chemother. 2016 Nov 21;60(12):7498-7501. doi: 10.1128/AAC.01165-16. Print 2016 Dec.
2
A Model for Transposition of the Colistin Resistance Gene mcr-1 by ISApl1.由ISApl1介导的黏菌素耐药基因mcr-1转座模型
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6973-6976. doi: 10.1128/AAC.01457-16. Print 2016 Nov.
3
Complete Sequences of mcr-1-Harboring Plasmids from Extended-Spectrum-β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae.产超广谱β-内酰胺酶和碳青霉烯酶的肠杆菌科细菌中携带mcr-1质粒的完整序列
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4
Dissemination of the mcr-1 colistin resistance gene.mcr-1 黏菌素耐药基因的传播
Lancet Infect Dis. 2016 Mar;16(3):289-90. doi: 10.1016/S1473-3099(16)00067-0.
5
Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae.耐碳青霉烯类肠杆菌科细菌中mcr-1黏菌素耐药基因的出现。
Lancet Infect Dis. 2016 Mar;16(3):287-8. doi: 10.1016/S1473-3099(16)00056-6. Epub 2016 Feb 1.
6
Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid.耐多药质粒携带的黏菌素耐药基因mcr-1
Lancet Infect Dis. 2016 Mar;16(3):283-4. doi: 10.1016/S1473-3099(16)00012-8. Epub 2016 Jan 8.
7
Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli.大肠杆菌临床分离株中质粒介导的碳青霉烯类和黏菌素耐药性
Lancet Infect Dis. 2016 Mar;16(3):281. doi: 10.1016/S1473-3099(16)00006-2. Epub 2016 Jan 8.
8
Investigation of a plasmid genome database for colistin-resistance gene mcr-1.针对黏菌素耐药基因mcr-1的质粒基因组数据库研究。
Lancet Infect Dis. 2016 Mar;16(3):284-5. doi: 10.1016/S1473-3099(16)00008-6. Epub 2016 Jan 8.
9
Co-occurrence of extended spectrum β lactamase and MCR-1 encoding genes on plasmids.质粒上超广谱β-内酰胺酶与MCR-1编码基因的共现。
Lancet Infect Dis. 2016 Mar;16(3):281-2. doi: 10.1016/S1473-3099(16)00007-4. Epub 2016 Jan 8.
10
Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany.德国产超广谱β-内酰胺酶和碳青霉烯酶的革兰氏阴性菌中的黏菌素耐药基因mcr-1
Lancet Infect Dis. 2016 Mar;16(3):282-3. doi: 10.1016/S1473-3099(16)00009-8. Epub 2016 Jan 8.

医院污水中携带耐黏菌素基因mcr-1的IncP质粒肺炎克雷伯菌

IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae from Hospital Sewage.

作者信息

Zhao Feifei, Feng Yu, Lü Xiaoju, McNally Alan, Zong Zhiyong

机构信息

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.

出版信息

Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.02229-16. Print 2017 Feb.

DOI:10.1128/AAC.02229-16
PMID:27895009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5278755/
Abstract

A Klebsiella pneumoniae strain of sequence type 313 (ST313) recovered from hospital sewage was found carrying the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP-type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to spread beyond the Enterobacteriaceae family.

摘要

从医院污水中分离出的一株序列型为313（ST313）的肺炎克雷伯菌携带质粒介导的黏菌素耐药基因mcr-1，该基因位于一个新的IncP-1分支的57 kb自我传递型IncP型质粒上，两侧被两份插入序列ISApl1包围。mcr-1位于自我传递的广宿主范围质粒上，这突出表明mcr-1有可能在肠杆菌科以外传播。