Karamese Murat, Aydin Hakan, Sengul Emin, Gelen Volkan, Sevim Cigdem, Ustek Duran, Karakus Emre
Department of Medical Microbiology, Faculty of Medicine, Kafkas University, Kars, Turkey, e-mail:
Iran J Immunol. 2016 Sep;13(3):220-8.
Probiotics are "live", beneficial microbes that provide important health benefits in their hosts. There is significant interest in the modulation and regulation of the immune function by probiotics.
To investigate the immunomodulatory effects of a probiotic mixture, including Lactobacillus and Bifidobacterium species, by detecting serum cytokine and immunoglobulin levels.
The rats were randomly divided into 4 groups. The first group was "Control group" and other 3 groups were probiotic application groups who received different doses of probiotics. The probiotic mixture included 12 probiotic bacteria, mostly Lactobacillus and Bifidobacterium strains. Probiotic mixture was administered to rats for 12 consecutive days. TNF-α, TGF-β, IL-1-β, IL-6, and IL-10 levels as well as serum IgG and IgA concentrations were detected in the sera after 12 days.
Probiotics led to a decrease in the levels of TNF-α, IL-6 and TGF-β; however, they led to increase in the serum levels of IL-10, IgG and IgA. There were significant differences between control group and probiotic application groups (p<0.05).
These data suggest that the commensal microbiota are important for stimulating both proinflammatory and regulatory responses in order to rapidly clear infections and minimize inflammation-associated tissue damage.
益生菌是“活的”有益微生物，能为宿主带来重要的健康益处。人们对益生菌调节免疫功能有着浓厚兴趣。
通过检测血清细胞因子和免疫球蛋白水平，研究包括乳酸杆菌属和双歧杆菌属在内的益生菌混合物的免疫调节作用。
将大鼠随机分为4组。第一组为“对照组”，其他3组为接受不同剂量益生菌的益生菌应用组。该益生菌混合物包含12种益生菌，主要是乳酸杆菌和双歧杆菌菌株。连续12天给大鼠施用益生菌混合物。12天后检测血清中TNF-α、TGF-β、IL-1-β、IL-6和IL-10水平以及血清IgG和IgA浓度。
益生菌导致TNF-α、IL-6和TGF-β水平降低；然而，它们导致血清IL-10、IgG和IgA水平升高。对照组和益生菌应用组之间存在显著差异（p<0.05）。
这些数据表明共生微生物群对于刺激促炎反应和调节反应很重要，以便快速清除感染并将炎症相关的组织损伤降至最低。
