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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Kramar R, Ulrich W, Hohenegger M

Institute of Medical Chemistry, University of Vienna, Austria.

Exp Pathol. 1989;36(2):97-103.

The influence of thyroxine pretreatment on prognosis and some renal enzymes of fatty acid degradation of mercuric chloride intoxicated rats was studied. 2. Survival rates as observed over 10 d after 1.5 to 6.0 mg mercuric chloride/kg i.p. were not influenced by thyroxine pretreatment. 3. A quarter of survivors of both groups developed renal hypertrophy more pronounced in animals not treated with thyroxine. 4. Fatty acyl-CoA oxidase, the rate limiting enzyme of peroxisomal beta-oxidation was found to be depressed by about 50% 2 d after intoxication. This effect was prevented by thyroxine pretreatment. The other enzyme activities (carnitine acetyltransferase, carnitine-palmitoyltransferase and crotonoyl-CoA dependent NAD+ reduction) are essentially not influenced neither by intoxication nor by thyroxine pretreatment. 5. It is concluded that the prognosis of the intoxication is not correlated with fatty acid degradation enzymes.

研究了甲状腺素预处理对氯化汞中毒大鼠预后及脂肪酸降解相关一些肾酶的影响。2. 腹腔注射1.5至6.0毫克氯化汞/千克后10天内观察到的存活率不受甲状腺素预处理的影响。3. 两组的四分之一幸存者出现肾肥大，未用甲状腺素治疗的动物中更为明显。4. 过氧化物酶体β-氧化的限速酶脂肪酸酰基辅酶A氧化酶在中毒后2天被发现降低约50%。甲状腺素预处理可防止这种作用。其他酶活性（肉碱乙酰转移酶、肉碱-棕榈酰转移酶和巴豆酰辅酶A依赖的NAD+还原）基本上不受中毒或甲状腺素预处理的影响。5. 得出结论，中毒的预后与脂肪酸降解酶无关。

Kramar R, Ulrich W, Hohenegger M

Institute of Medical Chemistry, University of Vienna, Austria.

Exp Pathol. 1989;36(2):97-103.

The influence of thyroxine pretreatment on prognosis and some renal enzymes of fatty acid degradation of mercuric chloride intoxicated rats was studied. 2. Survival rates as observed over 10 d after 1.5 to 6.0 mg mercuric chloride/kg i.p. were not influenced by thyroxine pretreatment. 3. A quarter of survivors of both groups developed renal hypertrophy more pronounced in animals not treated with thyroxine. 4. Fatty acyl-CoA oxidase, the rate limiting enzyme of peroxisomal beta-oxidation was found to be depressed by about 50% 2 d after intoxication. This effect was prevented by thyroxine pretreatment. The other enzyme activities (carnitine acetyltransferase, carnitine-palmitoyltransferase and crotonoyl-CoA dependent NAD+ reduction) are essentially not influenced neither by intoxication nor by thyroxine pretreatment. 5. It is concluded that the prognosis of the intoxication is not correlated with fatty acid degradation enzymes.

研究了甲状腺素预处理对氯化汞中毒大鼠预后及脂肪酸降解相关一些肾酶的影响。2. 腹腔注射1.5至6.0毫克氯化汞/千克后10天内观察到的存活率不受甲状腺素预处理的影响。3. 两组的四分之一幸存者出现肾肥大，未用甲状腺素治疗的动物中更为明显。4. 过氧化物酶体β-氧化的限速酶脂肪酸酰基辅酶A氧化酶在中毒后2天被发现降低约50%。甲状腺素预处理可防止这种作用。其他酶活性（肉碱乙酰转移酶、肉碱-棕榈酰转移酶和巴豆酰辅酶A依赖的NAD+还原）基本上不受中毒或甲状腺素预处理的影响。5. 得出结论，中毒的预后与脂肪酸降解酶无关。