Olczyk K, Kucharz E J, Wieczorek M, Szczebara M, Sonecki P
Silesian School of Medicine, Sosnowiec, Poland.
Arh Hig Rada Toksikol. 1990 Mar;41(1):1-6.
Intoxication of rats with mercuric chloride (0.5 mg Hg/kg of body weight, daily for 10 weeks) increased the hepatic contents of soluble and insoluble collagen and elastin. The increase was associated with elevated serum aminotransferase and alkaline phosphatase activities, and decreased total protein level in serum. Inflammatory changes were found in the liver. An increase in the fibrous protein content suggests that inflammatory reaction to mercuric chloride can result in hepatic fibrosis.
用氯化汞（0.5毫克汞/千克体重，每日一次，持续10周）使大鼠中毒，可增加肝脏中可溶性和不可溶性胶原蛋白及弹性蛋白的含量。这种增加与血清氨基转移酶和碱性磷酸酶活性升高以及血清总蛋白水平降低有关。在肝脏中发现了炎症变化。纤维蛋白含量的增加表明对氯化汞的炎症反应可导致肝纤维化。
