Shibayama Y
Department of Pathology, Osaka Medical College, Japan.
Exp Mol Pathol. 1989 Aug;51(1):48-55. doi: 10.1016/0014-4800(89)90006-3.
To clarify whether glycyrrhizin, the aqueous extract of licorice root and a drug for treatment of chronic active hepatitis, prevents the development of hepatic injury induced by carbon tetrachloride, allyl formate, and endotoxin, the present study was undertaken in rats. The treatment with glycyrrhizin 20 hr before carbon tetrachloride administration protected the development of the pericentral hepatocellular necrosis. Glycyrrhizin treatment 2 hr prior to the administration of allyl formate also inhibited the development of the periportal hepatocellular necrosis. However, glycyrrhizin did not protect the development of endotoxin-induced focal and random hepatocellular necrosis. These experimental results suggest that glycyrrhizin has no protective effect on hepatic injury following sinusoidal circulatory disturbance as seen in the case of endotoxin and that glycyrrhizin can protect against hepatotoxicity induced by the direct action on the hepatocytes due to hepatotoxins, such as carbon tetrachloride and allyl formate.
为了阐明甘草甜素（甘草根的水提取物，一种治疗慢性活动性肝炎的药物）是否能预防四氯化碳、甲酸烯丙酯和内毒素诱导的肝损伤，本研究在大鼠中进行。在给予四氯化碳前20小时用甘草甜素治疗可保护中央静脉周围肝细胞坏死的发展。在给予甲酸烯丙酯前2小时用甘草甜素治疗也可抑制门静脉周围肝细胞坏死的发展。然而，甘草甜素不能保护内毒素诱导的局灶性和散在性肝细胞坏死的发展。这些实验结果表明，甘草甜素对内毒素所致的肝损伤（如在肝窦循环障碍时所见）没有保护作用，而甘草甜素可以预防因肝毒素（如四氯化碳和甲酸烯丙酯）直接作用于肝细胞而诱导的肝毒性。
