微小RNA（miRNAs）的作用及其作为胃癌诊断和预后生物标志物的潜力。
Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer.
作者信息
da Silva Oliveira Kelly Cristina, Thomaz Araújo Taíssa Maíra, Albuquerque Camila Inagaki, Barata Gabriela Alcantara, Gigek Carolina Oliveira, Leal Mariana Ferreira, Wisnieski Fernanda, Rodrigues Mello Junior Fernando Augusto, Khayat André Salim, de Assumpção Paulo Pimentel, Rodriguez Burbano Rommel Mário, Smith Marília Cardoso, Calcagno Danielle Queiroz
机构信息
Kelly Cristina da Silva Oliveira, Taíssa Maíra Thomaz Araújo, Camila Inagaki Albuquerque, Gabriela Alcantara Barata, Fernando Augusto Rodrigues Mello Junior, André Salim Khayat, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Hospital Universitário João de Barros Barreto, Belém, PA 66073-000, Brazil.
出版信息
World J Gastroenterol. 2016 Sep 21;22(35):7951-62. doi: 10.3748/wjg.v22.i35.7951.
Abstract
Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.
摘要
基因表达表观遗传调控的改变在包括胃癌在内的许多疾病中起着重要作用。许多研究已经在这类癌症中鉴定出大量上调的致癌miRNA和下调的肿瘤抑制miRNA。在这篇综述中，我们概述了miRNA的作用，指出它们作为胃癌诊断和/或预后生物标志物的潜在用途。此外，我们讨论了多态性和表观遗传修饰对miRNA活性的影响。
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本文引用的文献
1
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J Cancer Res Clin Oncol. 2016 Jun;142(6):1201-12. doi: 10.1007/s00432-016-2139-y. Epub 2016 Mar 8.
2
Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway.Cullin 4A（CUL4A）是miR-9和miR-137的直接靶点，通过调节Hippo信号通路促进胃癌的增殖和侵袭。
Oncotarget. 2016 Mar 1;7(9):10037-50. doi: 10.18632/oncotarget.7048.
3
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4
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5
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6
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10
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