毛发中的药物：一种新的提取方法。

Drugs in hair: a new extraction procedure.

作者信息

Offidani C, Carnevale A, Chiarotti M

机构信息

Institute of Forensic Medicine, Università Cattolica del Sacro Cuore, Roma, Italy.

出版信息

Forensic Sci Int. 1989 Apr-May;41(1-2):35-9. doi: 10.1016/0379-0738(89)90233-8.

DOI:10.1016/0379-0738(89)90233-8

PMID:2767578

Abstract

An enzymatic hydrolysis of hair for drug detection is described. The results obtained with the suggested method are compared with those observed by chemical hydrolysis. Enzymatic digestion provides a high recovery (80%) for cocaine metabolite, while alkaline hydrolysis causes its chemical destruction. The two hydrolytic procedures yielded comparable results for morphine. The outlined procedure is recommended when unstable compounds are to be detected in hair.

摘要

本文描述了一种用于药物检测的毛发酶水解方法。将该建议方法所得结果与化学水解法所得结果进行了比较。酶消化法对可卡因代谢物的回收率很高（80%），而碱水解会导致其化学破坏。两种水解方法对吗啡产生了相当的结果。当要在毛发中检测不稳定化合物时，推荐采用上述方法。