BHF Centre for Research Excellence, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
BHF Centre for Research Excellence, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK; MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
Dev Cell. 2016 Sep 26;38(6):621-34. doi: 10.1016/j.devcel.2016.08.012.
Cell competition is a cell fitness-sensing mechanism conserved from insects to mammals that eliminates those cells that, although viable, are less fit than their neighbors. An important implication of cell competition is that cellular fitness is not only a cell-intrinsic property but is also determined relative to the fitness of neighboring cells: a cell that is of suboptimal fitness in one context may be "super-fit" in the context of a different cell population. Here we discuss the mechanisms by which cell competition measures and communicates cell fitness levels and the implications of this mechanism for development, regeneration, and tumor progression.
细胞竞争是一种从昆虫到哺乳动物都保守的细胞适应度感知机制，它会消除那些虽然存活但适应度不如其相邻细胞的细胞。细胞竞争的一个重要含义是，细胞的适应度不仅是细胞内在的特性，而且还取决于相邻细胞的适应度：在一种情况下适应度较差的细胞，在另一种不同的细胞群体情况下可能“超适应”。在这里，我们讨论了细胞竞争测量和传达细胞适应度水平的机制，以及该机制对发育、再生和肿瘤进展的影响。
