细胞竞争促进侵袭性癌细胞的选择。
Cell Competition Spurs Selection of Aggressive Cancer Cells.
机构信息
Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal.
Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
出版信息
Trends Cancer. 2020 Sep;6(9):732-736. doi: 10.1016/j.trecan.2020.03.008. Epub 2020 Apr 20.
PMID:32327348
Abstract
Within heterogeneous tumors, cancer cells are constantly interacting. Cell competition (CC) is a fitness-based selection mechanism that results in increased proliferation of discrete populations at the expense of their less fit neighbors. CC-based selection of fit cells may also drive selection of the most aggressive cancer cells.
摘要
在异质性肿瘤中，癌细胞不断相互作用。细胞竞争（CC）是一种基于适应性的选择机制，导致离散群体的增殖增加，而代价是其适应性较差的邻居。基于 CC 的适应性细胞选择也可能驱动最具侵袭性的癌细胞的选择。
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