Michaelsen Kelly E, Krishnaswamy Venkataramanan, Shi Linxi, Vedantham Srinivasan, Karellas Andrew, Pogue Brian W, Paulsen Keith D, Poplack Steven P
Dartmouth College, Thayer School of Engineering, 14 Engineering Drive, Hanover, New Hampshire 03755, United States.
Georgia Institute of Technology, School of Mechanical Engineering, 801 Ferst Drive, Atlanta, Georgia 30332, United States.
J Biomed Opt. 2016 Sep 1;21(9):91316. doi: 10.1117/1.JBO.21.9.091316.
Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast tomosynthesis (DBT). Image data were analyzed from 27 women who underwent four IRB approved NIRST/DBT exams that included fully and mildly compressed breast acquisitions in two projections—craniocaudal (CC) and mediolateral-oblique (MLO)—and generated four data sets per patient (full and moderate compression in CC and MLO views). Breast density was correlated with HbT (r=0.64, p=0.001), water (r=0.62, p=0.003), and lipid concentrations (r=?0.74, p<0.001), but not oxygen saturation. CC and MLO views were correlated for individual subjects and demonstrated no statistically significant differences in grouped analysis. Comparison of compressed and uncompressed imaging demonstrated a significant decrease in oxygen saturation under compression (58% versus 50%, p=0.04). Mammographic breast density categorization was correlated with measured optically derived properties.
通过一个将近红外光谱断层扫描（NIRST）与数字乳腺断层合成（DBT）相结合的配准成像系统，获得了一系列乳腺密度下的光学衍生组织特性，以及乳腺压迫对血红蛋白、氧代谢、水和脂质浓度估计值的影响。对27名女性的图像数据进行了分析，这些女性接受了四项经机构审查委员会（IRB）批准的NIRST/DBT检查，包括在头尾位（CC）和内外斜位（MLO）两个投影方向上对乳腺进行完全压迫和轻度压迫采集，每位患者生成四个数据集（CC和MLO视图下的完全压迫和中度压迫）。乳腺密度与总血红蛋白（HbT）（r = 0.64，p = 0.001）、水（r = 0.62，p = 0.003）和脂质浓度（r = -0.74，p < 0.001）相关，但与氧饱和度无关。CC和MLO视图在个体受试者中具有相关性，并且在分组分析中未显示出统计学上的显著差异。压缩成像与未压缩成像的比较表明，压迫下氧饱和度显著降低（58%对50%，p = 0.04）。乳腺钼靶密度分类与测量得到的光学衍生特性相关。
