Davies Olubanke, Ustianowski Andrew, Fox Julie
Department of Genitourinary Medicine, Guys and St Thomas' NHS Trust, London, UK.
Infectious Diseases, North Manchester General Hospital, Manchester, UK.
Infect Dis Ther. 2016 Dec;5(4):407-416. doi: 10.1007/s40121-016-0128-8. Epub 2016 Sep 27.
Pre-exposure prophylaxis (PrEP) offers a promising new approach to HIV prevention. It is protective against HIV infection across populations and has few significant safety risks and little evidence of behavioural risk compensation. This article summarises the evidence behind HIV PrEP as an intervention, populations that may benefit, current guidelines and programmes, and the cost-effectiveness modelling of this strategy.
暴露前预防(PrEP)为艾滋病病毒(HIV)预防提供了一种有前景的新方法。它对所有人群预防HIV感染均有作用,且几乎没有重大安全风险,也几乎没有行为风险补偿的证据。本文总结了HIV暴露前预防作为一种干预措施的依据、可能受益的人群、现行指南和项目,以及该策略的成本效益模型。