Roy Priyabrata, Bodhak Chandan, Pramanik Animesh
Department of Chemistry, University of Calcutta, 92, A.P.C. Road, Kolkata, 700009, India.
Department of Chemistry, Victoria Institution (College), 78B, A.P.C. Road, Kolkata, 700009, India.
Mol Divers. 2017 Feb;21(1):89-100. doi: 10.1007/s11030-016-9701-z. Epub 2016 Sep 27.
A one-pot three-component protocol has been developed for the synthesis of amino ester-embedded benzimidazoles under metal-free neutral conditions. Sequentially, the methodology involves coupling of an amino ester with 1-fluoro-2-nitrobenzene, reduction of the coupled nitroarene by sodium dithionite, and cyclization of the corresponding diamine with an aldehyde.
已开发出一种一锅三组分方法，用于在无金属中性条件下合成嵌入氨基酯的苯并咪唑。该方法依次包括氨基酯与1-氟-2-硝基苯的偶联、连二亚硫酸钠对偶联硝基芳烃的还原，以及相应二胺与醛的环化反应。
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