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J Med Chem. 2012 Jun 14;55(11):5291-310. doi: 10.1021/jm300276x. Epub 2012 May 31.
2
Evaluation and discovery of novel synthetic chalcone derivatives as anti-inflammatory agents.评估和发现新型合成查耳酮衍生物作为抗炎剂。
J Med Chem. 2011 Dec 8;54(23):8110-23. doi: 10.1021/jm200946h. Epub 2011 Nov 4.
3
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4
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J Med Chem. 2011 Jun 9;54(11):3768-78. doi: 10.1021/jm200017g. Epub 2011 May 16.
5
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新型苯并咪唑和咪唑并吡啶衍生物的合成与抗炎活性评价

Synthesis and Anti-inflammatory Evaluation of Novel Benzimidazole and Imidazopyridine Derivatives.

作者信息

Chen Gaozhi, Liu Zhiguo, Zhang Yali, Shan Xiaoou, Jiang Lili, Zhao Yunjie, He Wenfei, Feng Zhiguo, Yang Shulin, Liang Guang

机构信息

School of Pharmacy, Wenzhou Medical College , 1210 University Town, Wenzhou, Zhejiang 325035, China.

School of Environmental and Biological Engineering, Nanjing University of Science and Technology , 200 Xiaolingwei St., Nanjing, Jiangsu 210094, China.

出版信息

ACS Med Chem Lett. 2012 Nov 21;4(1):69-74. doi: 10.1021/ml300282t. eCollection 2013 Jan 10.

DOI:10.1021/ml300282t
PMID:24900565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4027431/
Abstract

Sepsis, an acute inflammatory disease, remains the most common cause of death in intensive care units. A series of benzimidazole and imidazopyridine derivatives were synthesized and screened for anti-inflammatory activities, and the imidazopyridine series showed excellent inhibition of the expression of inflammatory cytokines in LPS-stimulated macrophages. Compounds X10, X12, X13, X14, and X15 inhibited TNF-α and IL-6 release in a dose-dependent manner, and X12 showed no cytotoxicity in hepatic cells. Furthermore, X12 exhibited a significant protection against LPS-induced septic death in mouse models. Together, these data present a series of new imidazopyridines with potential therapeutic effects in acute inflammatory diseases.

摘要

脓毒症是一种急性炎症性疾病，仍然是重症监护病房中最常见的死亡原因。合成了一系列苯并咪唑和咪唑并吡啶衍生物并筛选其抗炎活性，咪唑并吡啶系列在脂多糖刺激的巨噬细胞中对炎性细胞因子的表达表现出优异的抑制作用。化合物X10、X12、X13、X14和X15以剂量依赖性方式抑制肿瘤坏死因子-α和白细胞介素-6的释放，并且X12在肝细胞中无细胞毒性。此外，在小鼠模型中，X12对脂多糖诱导的脓毒症死亡表现出显著的保护作用。总之，这些数据展示了一系列在急性炎症性疾病中具有潜在治疗作用的新型咪唑并吡啶。