Wimmer M
Anatomisches Institut der Universität Basel, Switzerland.
Histochemistry. 1989;92(2):109-13. doi: 10.1007/BF00490228.
Phosphoenolpyruvate carboxykinase (PEPCK) activity was investigated in livers of triiodothyronine (T3) treated male and female rats with special regard to its intraacinar localization. In untreated controls of both, male and female rats, the activity was heterotopically distributed within the acinus with highest values in the periportal zone, and with lowest values in the perivenous zone. This periportal to perivenous activity gradient revealed to be under the influence of T3. Application of T3 resulted in a relative increase of PEPCK activity which was much greater in the livers of females than in males. The extent of T3-induced augmentation of PEPCK activity was dependent on the intraacinar position. In both sexes greatest relative activation was found in the perivenous zone. In female animals, the perivenous activity of T3 treated livers was comparable to that observed in the periportal zone of controls.
研究了三碘甲状腺原氨酸（T3）处理的雄性和雌性大鼠肝脏中的磷酸烯醇丙酮酸羧激酶（PEPCK）活性，特别关注其腺泡内定位。在未处理的雄性和雌性大鼠对照组中，该活性在腺泡内呈异位分布，在门静脉周围区域活性最高，在肝静脉周围区域活性最低。这种从门静脉周围到肝静脉周围的活性梯度显示受T3影响。给予T3导致PEPCK活性相对增加，雌性大鼠肝脏中的增加幅度远大于雄性。T3诱导的PEPCK活性增强程度取决于腺泡内位置。在两性中，肝静脉周围区域的相对激活程度最大。在雌性动物中，T3处理肝脏的肝静脉周围活性与对照组门静脉周围区域观察到的活性相当。
