Wimmer M, Luttringer C, Colombi M
Anatomisches Institut der Universität Basel, Switzerland.
Histochemistry. 1990;94(1):55-9. doi: 10.1007/BF00266790.
The postnatal appearance of phosphoenolpyruvate carboxykinase activity (PEPCK) and acinar heterotopy was investigated in newborn rats aged 2 h, 12 h, 24 h and 3 days, as well as in juvenile rats aged 25 days. The livers showed an almost homogeneous distribution of activity along the sinusoidal length at the beginning of extrauterine life where energy needs are greatest. Compared to rats aged 2 h, the PEPCK activity was higher in the livers from rats aged 12 h. The increase in activity was most pronounced in the intermediary zone. After 24 h of extrauterine life the activity decreased again creating a homogeneous acinar activity pattern. By day 3 activity had increased in the periportal zone, while decreasing in the perivenous zone, resulting in a periportal to perivenous gradient. By day 25 total activity had reached highest values both in males and females, due to a relatively high perivenous activity. The more prominent acinar gradient corresponded approximately to the one seen in adult animals.
研究了出生后2小时、12小时、24小时和3天的新生大鼠以及25天的幼年大鼠中磷酸烯醇丙酮酸羧激酶活性（PEPCK）和腺泡异位的情况。在宫外生活开始时，肝脏沿窦状隙长度呈现出几乎均匀的活性分布，此时能量需求最大。与2小时龄的大鼠相比，12小时龄大鼠肝脏中的PEPCK活性更高。活性增加在中间带最为明显。宫外生活24小时后，活性再次下降，形成均匀的腺泡活性模式。到第3天，门周区活性增加，而中央静脉周围区活性降低，导致从门周区到中央静脉周围区的梯度。到第25天，由于相对较高的中央静脉周围区活性，雄性和雌性大鼠的总活性均达到最高值。更明显的腺泡梯度大致与成年动物中所见的梯度相符。
