Wimmer M, Luttringer C, Colombi M
Anatomisches Institut der Universität Basel, Switzerland.
Histochemistry. 1990;93(3):257-62. doi: 10.1007/BF00266386.
Phosphoenolpyruvate carboxykinase (PEPCK) activity was investigated in relation to its localization within the liver acinus of male and female rats after feeding either a high protein diet (77%) or a high fat diet (52%). Both diets led to sex-dependent changes in activity and acinar distribution patterns. In male rats high protein diet provoked a shift in the acinar activity pattern towards the perivenous parts of the acinus without increase in average activity. Yet in the livers of females the activity was increased in all parts of the acinus, but to a greater extent in the perivenous parts of the acinus. Feeding a high fat diet increased PEPCK activity in males and to an even greater extent in females. In both sexes the increase was greater in the perivenous zone when compared to the changes within the periportal zone. The results are discussed in relation to changes in the concentrations of glucoregulatory hormones.
研究了高蛋白饮食（77%）或高脂肪饮食（52%）喂养后，雄性和雌性大鼠肝脏腺泡内磷酸烯醇丙酮酸羧激酶（PEPCK）的活性与其定位的关系。两种饮食均导致活性和腺泡分布模式的性别依赖性变化。在雄性大鼠中，高蛋白饮食促使腺泡活性模式向腺泡的静脉周围部分转移，但平均活性并未增加。然而，在雌性大鼠的肝脏中，腺泡各部分的活性均增加，但在腺泡的静脉周围部分增加程度更大。喂养高脂肪饮食会增加雄性大鼠的PEPCK活性，在雌性大鼠中增加程度更大。与门静脉周围区域的变化相比，两性的静脉周围区域增加幅度更大。结合血糖调节激素浓度的变化对结果进行了讨论。
