Go Yukyung, Chung Minsung, Park Yongsoon
a Department of Food and Nutrition , Hanyang University , Seoul , Korea.
b Department of Surgery , College of Medicine, Hanyang University , Seoul , Korea.
Nutr Cancer. 2016 Nov-Dec;68(8):1281-1288. doi: 10.1080/01635581.2016.1225102. Epub 2016 Sep 28.
Triple-negative breast cancer (TNBC) is a common subtype of breast cancer among women with dense breasts and is associated with a poor prognosis. Diet is a modifiable risk factor for breast cancer, but the association between the risk of TNBC and diet has not been studied. The present study investigated the hypothesis that a healthy dietary pattern was negatively associated with risk of TNBC in women with dense breasts (density types 3 and 4). After total mastectomy or breast conserving surgery, patients with TNBC (n = 38) and non-TNBC (n = 178) were recruited. The risk of TNBC was negatively associated with a healthy dietary pattern involving consumption of seafood and vegetables, and positively associated with a dietary pattern of consuming grains, meats, and eggs. Additionally, intake of animal fat, eggs, and meat was positively associated with the risk of TNBC, but intake of vegetable fats, nuts, and vegetables showed a negative association. Patients with TNBC had higher proportion of obesity or abdominal obesity than those with non-TNBC. The present study is the first to show a negative association between risk of TNBC and a healthy dietary pattern in women with dense breasts and suggests the importance of diet in the prevention of TNBC.
三阴性乳腺癌（TNBC）是乳腺致密女性中常见的乳腺癌亚型，且与预后不良相关。饮食是乳腺癌的一个可改变风险因素，但TNBC风险与饮食之间的关联尚未得到研究。本研究调查了这样一个假设：健康的饮食模式与乳腺致密（密度类型3和4）女性的TNBC风险呈负相关。在全乳切除或保乳手术后，招募了TNBC患者（n = 38）和非TNBC患者（n = 178）。TNBC风险与包含食用海鲜和蔬菜的健康饮食模式呈负相关，与食用谷物、肉类和蛋类的饮食模式呈正相关。此外，动物脂肪、蛋类和肉类的摄入量与TNBC风险呈正相关，但植物脂肪、坚果和蔬菜的摄入量呈负相关。TNBC患者比非TNBC患者有更高比例的肥胖或腹型肥胖。本研究首次表明乳腺致密女性的TNBC风险与健康饮食模式之间存在负相关，并提示了饮食在预防TNBC中的重要性。
