Joyce D P, Murphy D, Lowery A J, Curran C, Barry K, Malone C, McLaughlin R, Kerin M J
Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Ireland.
Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway, Ireland.
Surgeon. 2017 Oct;15(5):272-277. doi: 10.1016/j.surge.2016.10.001. Epub 2016 Oct 27.
Triple-negative breast cancers (TNBC) are associated with a poor prognosis owing to an aggressive phenotype. We aimed to carry out a prospective study comparing management strategies and response to therapy in TNBC and non-TNBC patients.
Data were obtained from a prospectively maintained database of patients treated for breast cancer.
A total of 142 TNBC and 142 age-, stage- and NPI-matched non-TNBC patients were treated. The difference in overall survival between the 2 groups was statistically significant (77% of TNBC patients alive at a mean follow-up of 32 months, versus 92% of non-TNBC patients at a mean follow-up of 38 months, P = 0.0 Log rank test). This survival difference was found to be independent of NPI (P = 0.0 Log rank test). Locoregional recurrence rates were similar between TNBC patients who were treated with wide local excision versus mastectomy (P = 0.449 Log rank test). A significant difference in survival was noted between TNBC patients who responded differentially to neoadjuvant chemotherapy (P = 0.035 Log rank test).
Patients with TNBC have adverse outcomes despite aggressive treatment. The development of effective targeted therapies is essential for this breast cancer subtype.
三阴性乳腺癌（TNBC）因其侵袭性表型而预后较差。我们旨在开展一项前瞻性研究，比较TNBC和非TNBC患者的治疗策略及对治疗的反应。
数据来自一个前瞻性维护的乳腺癌患者数据库。
共治疗了142例TNBC患者和142例年龄、分期及诺丁汉预后指数（NPI）匹配的非TNBC患者。两组患者的总生存率差异具有统计学意义（TNBC患者在平均32个月的随访中有77%存活，而非TNBC患者在平均38个月的随访中有92%存活，P = 0.0对数秩检验）。发现这种生存差异与NPI无关（P = 0.0对数秩检验）。接受广泛局部切除与乳房切除术的TNBC患者局部区域复发率相似（P = 0.449对数秩检验）。对新辅助化疗反应不同的TNBC患者生存存在显著差异（P = 0.035对数秩检验）。
尽管进行了积极治疗，TNBC患者的预后仍较差。开发有效的靶向治疗对这种乳腺癌亚型至关重要。
