Qiu Xiao-Yuan, Sun Lu, Han Xue-Ling, Chang Ying, Cheng Lan, Yin Li-Rong
a Department of Obstetrics and Gynecology , The Second Hospital of Tianjin Medical University , Tianjin , People's Republic of China and.
b Department of Obstetrics , Tianjin Central Hospital of Gynecology Obstetrics, Tianjin Medical University , Tianjin , People's Republic of China.
Gynecol Endocrinol. 2017 Feb;33(2):128-131. doi: 10.1080/09513590.2016.1214260. Epub 2016 Aug 12.
Chorioamnionitis is associated with an increased risk of spontaneous preterm birth. The aim of this study was to investigate the serum levels of high mobility group box-1 (HMGB1) in pregnancies with histological chorioamnionitis (HCA)-associated preterm labor (PTL) with intact membranes or preterm premature rupture of membranes (PPROM), and to access the role of serum HMGB1 in HCA and HCA-associated PTL. A total of 190 pregnant women were enrolled in this study: PLT patients with (n = 28) or without HCA (n = 36), PPROM patients with (n = 26) or without HCA (n = 65), and non-HCA PTL controls (n = 35). Maternal serum levels of HMGB1 were measured by enzyme-linked immunosorbent assay. Serum HMGB1 levels were significantly higher in PTL or PPROM patients than in control group (p < 0.01, respectively). The PPROM patients also exhibited higher serum HMGB1 levels compared to PTL patients (p = 0.015). HCA patients were characterized by significantly increased levels of serum HMGB1 when compared with non-HCA patients (p < 0.01). Therefore, maternal serum HMGB1 may become a potential biomarker of HCA and HCA-associated PTL.
绒毛膜羊膜炎与自然早产风险增加相关。本研究的目的是调查组织学绒毛膜羊膜炎（HCA）相关早产（PTL）且胎膜完整或胎膜早破（PPROM）孕妇的血清高迁移率族蛋白B1（HMGB1）水平，并探讨血清HMGB1在HCA及HCA相关PTL中的作用。本研究共纳入190名孕妇：有（n = 28）或无HCA（n = 36）的PTL患者、有（n = 26）或无HCA（n = 65）的PPROM患者以及非HCA PTL对照组（n = 35）。采用酶联免疫吸附测定法检测孕妇血清HMGB1水平。PTL或PPROM患者的血清HMGB1水平显著高于对照组（p分别<0.01）。与PTL患者相比，PPROM患者的血清HMGB1水平也更高（p = 0.015）。与非HCA患者相比，HCA患者的血清HMGB1水平显著升高（p<0.01）。因此，孕妇血清HMGB1可能成为HCA及HCA相关PTL的潜在生物标志物。
