Xiaolin Gu M M
a Department of Neurology , Internal Medicine-Neurology , Hangzhou First People's Hospital , Hangzhou , China.
Top Stroke Rehabil. 2017 Jan;24(1):34-40. doi: 10.1080/10749357.2016.1188474. Epub 2016 Aug 12.
The study aimed to evaluate potential risk factors of sleep disorder in stroke patients by conducting a meta-analysis.
Relevant articles were searched in PubMed, Medline, Springer, Elsevier, Science Direct, Cochrane Library, and Google scholar database up to May 2014. The effect size of risk factors, including gender, hypertension, diabetes mellitus, dyslipidemia, smoking, alcohol use, previous stroke, chronic obstructive pulmonary disease (COPD), and habitual snoring were measured by odds ratio (OR) and corresponding 95% confidence interval (95% CI). The heterogeneity of effect size across studies was evaluated by applying Cochran's Q-statistic and the I statistic. In addition, Egger's linear regression test was used to evaluate the publication bias.
A total of 8 studies, involving 1381 stroke patients (578 patients with sleep disorder, and 803 patients without sleep disorder) were suitable for this meta-analysis. Pooled results showed significant association of sleep disorder risk in stoke patients with diabetes mellitus (OR = 1.42, 95% CI = 1.09-1.85), alcohol use (OR = 1.59, 95% CI = 1.19-2.12) and habitual snoring (OR = 14.77, 95% CI = 5.52-39.53). No significant association was found between risk of sleep disorder in stoke patients and other factors. Furthermore, heterogeneity was just presented among studies involving gender, hypertension and smoking. Egger's linear regression test showed no statistical publication bias.
Diabetes mellitus, alcohol use, and habitual snoring are associated with a significantly increased risk of sleep disorder in stroke patients.
(1) Eight studies containing 1381 patients are included in this meta-analysis. (2) Diabetes mellitus was associated with sleep disorder in stroke patients. (3) Alcohol use could increase the risk of sleep disorder in stroke patients. (4) Habitual snoring was obviously associated with sleep disorder in stroke patients.
本研究旨在通过进行一项荟萃分析来评估中风患者睡眠障碍的潜在风险因素。
截至2014年5月，在PubMed、Medline、Springer、Elsevier、Science Direct、Cochrane图书馆和谷歌学术数据库中检索相关文章。通过比值比（OR）及相应的95%置信区间（95%CI）来衡量包括性别、高血压、糖尿病、血脂异常、吸烟、饮酒、既往中风、慢性阻塞性肺疾病（COPD）和习惯性打鼾等风险因素的效应大小。应用Cochran's Q统计量和I统计量评估各研究间效应大小的异质性。此外，采用Egger线性回归检验评估发表偏倚。
共有8项研究，涉及1381例中风患者（578例有睡眠障碍，803例无睡眠障碍）适合本荟萃分析。汇总结果显示，中风患者睡眠障碍风险与糖尿病（OR = 1.42，95%CI = 1.09 - 1.85）、饮酒（OR = 1.59，95%CI = 1.19 - 2.12）和习惯性打鼾（OR = 14.77，95%CI = 5.52 - 39.53）显著相关。未发现中风患者睡眠障碍风险与其他因素之间存在显著关联。此外，仅在涉及性别、高血压和吸烟的研究之间存在异质性。Egger线性回归检验未显示有统计学意义的发表偏倚。
糖尿病、饮酒和习惯性打鼾与中风患者睡眠障碍风险显著增加相关。
（1）本荟萃分析纳入了8项研究，共1381例患者。（2）糖尿病与中风患者的睡眠障碍相关。（3）饮酒会增加中风患者睡眠障碍的风险。（4）习惯性打鼾与中风患者的睡眠障碍明显相关。
