Knudsen M
Institute of Electronic Systems, Aalborg University, Denmark.
Int J Hyperthermia. 1989 Sep-Oct;5(5):653-61. doi: 10.3109/02656738909140488.
During hyperthermia treatment of patients the delivered heat and the temperatures at several points in the tissue are often measured and recorded. These data contain information about thermal tissue parameters. A method for extracting this information, i.e. estimating the tissue parameters--in particular the blood perfusion rate--is described. The method applies a system identification technique, adjusting the unknown parameters in a thermal tissue model, until the predicted model output (temperature) coincides well with the measured temperature. Data from a number of patient treatments have been used to test the method, and although the accuracy of the method remains to be established conclusively it appears to give a good estimate of the model parameter representing blood flow. The obvious advantage of the method is that it requires no special transducers or experiments. The weak aspect is that it depends on the correctness of a thermal model of the perfused tissue.
在对患者进行热疗期间，通常会测量并记录传递的热量以及组织中多个点的温度。这些数据包含有关热组织参数的信息。本文描述了一种提取此信息的方法，即估计组织参数，特别是血液灌注率。该方法应用系统识别技术，调整热组织模型中的未知参数，直到预测的模型输出（温度）与测量温度良好吻合。已使用来自多个患者治疗的数据来测试该方法，尽管该方法的准确性仍有待最终确定，但它似乎能很好地估计代表血流的模型参数。该方法的明显优点是不需要特殊的换能器或实验。其不足之处在于它依赖于灌注组织热模型的正确性。
