乙醇脱氢酶1B（ADH1B）和钙黏蛋白1（CDH1）基因多态性可预测非转移性喉癌男性患者的预后。
ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer.
作者信息
Li Daxu, Zhang Ruizhi, Jin Tianbo, He Na, Ren Le, Zhang Zhe, Zhang Qingna, Xu Ran, Tao Hong, Zeng Guang, Gao Jing
机构信息
Department of Stomatology, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710061, China.
Department of Stomatology, Ankang Central Hospital, Ankang 725000, Shaanxi.
出版信息
Oncotarget. 2016 Nov 8;7(45):73216-73228. doi: 10.18632/oncotarget.12301.
In this study, we assessed the association between single nucleotide polymorphisms (SNPs) in candidate genes and the prognosis of laryngeal cancer (LC) patients. Thirty-seven SNPs in 26 genes were genotyped in 170 male Han Chinese patients with LC. The effects of the candidate genes on the prognosis of LC patients were evaluated using Kaplan-Meier curves and Cox proportional hazards regression models. The GA genotype of rs1229984 (hazard ratio [HR], 0.537; 95% confidence interval [CI], 0.340-0.848; p = 0.008) in alcohol dehydrogenase 1B (ADH1B), and the AA genotype of rs9929218 (HR, 6.074; 95% CI, 1.426-25.870; p = 0.015) in CDH1 were associated with overall survival. Our data suggest that polymorphisms in ADH1B and CDH1 may be prognostic indicators in LC.
在本研究中，我们评估了候选基因中的单核苷酸多态性（SNP）与喉癌（LC）患者预后之间的关联。对170例汉族男性LC患者的26个基因中的37个SNP进行了基因分型。使用Kaplan-Meier曲线和Cox比例风险回归模型评估候选基因对LC患者预后的影响。酒精脱氢酶1B（ADH1B）基因的rs1229984的GA基因型（风险比[HR]，0.537；95%置信区间[CI]，0.340 - 0.848；p = 0.008）以及钙黏蛋白1（CDH1）基因的rs9929218的AA基因型（HR，6.074；95%CI，1.426 - 25.870；p = 0.015）与总生存期相关。我们的数据表明，ADH1B和CDH1基因的多态性可能是LC的预后指标。
Zotero 插件