酒精脱氢酶-乙醛脱氢酶多态性对下咽癌患者临床结局的影响。
Impact of alcohol dehydrogenase-aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer.
作者信息
Avinçsal Mehmet Ozgur, Shinomiya Hirotaka, Teshima Masanori, Kubo Mie, Otsuki Naoki, Kyota Naomi, Sasaki Ryohei, Zen Yoh, Nibu Ken-Ichi
机构信息
Department of Otolaryngology - Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.
出版信息
Head Neck. 2018 Apr;40(4):770-777. doi: 10.1002/hed.25050. Epub 2017 Dec 29.
BACKGROUND
The purpose of this research was to investigate the association between alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) polymorphisms and hypopharyngeal squamous cell carcinoma (SCC) survival.
METHODS
We genotyped ADH1B (rs1229984) and ALDH2 (rs671) single nucleotide polymorphisms (SNPs) in 85 Japanese male patients with hypopharyngeal SCC. The independent prognostic values of ADH1B-ALDH2 genotypes were analyzed by univariate and multivariate proportional hazard Cox regression, taking well-known clinical risk factors into account.
RESULTS
Heavy drinkers with ALDH22 allele resulted in significantly worse overall survival (OS; P = .028) and disease-free survival (DFS; P = .029) compared with other patients. Heavy drinkers with ALDH22 allele remained statistically significant in multivariate analysis for OS and DFS, indicating independent poor prognostic factor (hazard ratio [HR] 2.251; 95% confidence interval [CI] 1.018-4.975 and HR 2.261; 95% CI 1.021-5.006, respectively).
CONCLUSION
We conclude that heavy drinkers with the ALDH2*2 allele are associated with poor outcome in hypopharyngeal SCC.
背景
本研究旨在探讨乙醇脱氢酶1B（ADH1B）和乙醛脱氢酶2（ALDH2）基因多态性与下咽鳞状细胞癌（SCC）生存率之间的关联。
方法
我们对85例日本男性下咽SCC患者的ADH1B（rs1229984）和ALDH2（rs671）单核苷酸多态性（SNP）进行了基因分型。在考虑众所周知的临床风险因素的情况下，通过单因素和多因素比例风险Cox回归分析ADH1B-ALDH2基因型的独立预后价值。
结果
与其他患者相比，携带ALDH22等位基因的重度饮酒者的总生存期（OS；P = 0.028）和无病生存期（DFS；P = 0.029）明显更差。在多因素分析中，携带ALDH22等位基因的重度饮酒者的OS和DFS仍具有统计学意义，表明其为独立的不良预后因素（风险比[HR]分别为2.251；95%置信区间[CI]为1.018 - 4.975和HR 2.261；95%CI为1.021 - 5.006）。
结论
我们得出结论，携带ALDH2*2等位基因的重度饮酒者在下咽SCC中预后较差。
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