Moriyama S, Shimizu N, Kurita A, Teramoto S, Taguchi K
Nihon Kyobu Geka Gakkai Zasshi. 1989 Apr;37(4):717-22.
A case of adenocarcinoma of the thymus is reported in this paper. To the best of our knowledge, this is the first case of thymic adenocarcinoma in the world literature. A 51-year-old female was admitted to our hospital because of hyperthyroidism and anterior mediastinal tumor. After control of hyperthyroidism, thoracotomy was performed and the tumor was located in the right lobe of the thymus macroscopically. The tumor was extirpated and the specimen was revealed to be multiple thymic cyst with papillo-tubular adenocarcinoma proliferating in one of the cysts. The variability of the lining cells i.e. squamous, cuboidal, columnar, and transitional cell, suggest that the thymic cyst is of congenital origin and the adenacarcinoma is originated from multipotential lining cells of the cyst. She has no evidence of recurrence for 14 years postoperatively, therefore there is almost no possibility of metastasis from other organ to the anterior mediastinum.
本文报道了一例胸腺腺癌病例。据我们所知,这是世界文献中首例胸腺腺癌病例。一名51岁女性因甲状腺功能亢进和前纵隔肿瘤入住我院。在控制甲状腺功能亢进后,进行了开胸手术,肉眼可见肿瘤位于胸腺右叶。肿瘤被切除,标本显示为多个胸腺囊肿,其中一个囊肿内有乳头管状腺癌增生。内衬细胞的变异性,即鳞状、立方状、柱状和移行细胞,提示胸腺囊肿为先天性起源,腺癌起源于囊肿的多能内衬细胞。术后14年她无复发迹象,因此几乎不存在其他器官转移至前纵隔的可能性。