De Salvo G, Vaz-Pereira S, Arora R, Lotery A J
Southampton Eye Unit, University Hospital Southampton Foundation Trust, Southampton, UK.
Department of Ophthalmology, Hospital de Santa Maria, Lisbon, Portugal.
Eye (Lond). 2017 Jan;31(1):127-131. doi: 10.1038/eye.2016.193. Epub 2016 Sep 30.
PurposeTo study the usefulness of multicolor imaging (MC) photographs in addition to near infrared reflectance (NIR) and spectral domain optical coherence tomography (SD-OCT) in the detection and follow up of acute macular neuroretinopathy (AMN).Patients and methodsSix patients with a complaint of paracentral scotomas in at least one eye due to AMN were included. They underwent full ophthalmic examination and multimodal imaging including color fundus photographs, (SD-OCT), NIR, and MC at baseline and follow up.ResultsFour females and two males, aged 19-64 years, and eight eyes affected by AMN, were included. Acute phase SD-OCT in all patients confirmed the diagnosis of type 2 AMN with partial recovery of the outer retina in the convalescent phase. NIR and MC elicited in all cases hypo-reflective AMN lesions pointing toward the fovea. MC exhibited a higher contrast between the affected and the physiologic retina that slowly attenuated during the follow up showing a decrease in the hypo-reflectance of the lesions.ConclusionMC imaging was more detailed than fundus color photographs and as detailed as NIR in the detection of AMN. When available, MC imaging should complement SD-OCT and NIR in the diagnosis and follow up of this rare inflammatory condition that may be underdiagnosed.
目的
研究除近红外反射（NIR）和光谱域光学相干断层扫描（SD - OCT）外，多色成像（MC）照片在急性黄斑神经视网膜病变（AMN）检测和随访中的作用。
患者与方法
纳入6例因AMN至少一只眼出现旁中心暗点的患者。他们在基线期和随访期接受了全面的眼科检查和多模态成像，包括彩色眼底照片、（SD - OCT）、NIR和MC。
结果
纳入4名女性和2名男性，年龄19 - 64岁，8只眼受AMN影响。所有患者急性期的SD - OCT均确诊为2型AMN，恢复期外层视网膜部分恢复。NIR和MC在所有病例中均显示指向黄斑中心凹的低反射性AMN病变。MC显示病变视网膜与正常视网膜之间的对比度更高，随访期间该对比度缓慢减弱，病变的低反射性降低。
结论
在检测AMN方面，MC成像比彩色眼底照片更详细，与NIR一样详细。如有条件，MC成像应在这种可能诊断不足的罕见炎症性疾病的诊断和随访中补充SD - OCT和NIR。
