Fers-Lidou Anthony, Berger Olivier, Montchamp Jean-Luc
Department of Chemistry and Biochemistry, TCU Box 298860, Texas Christian University, Fort Worth, TX 76129, USA.
Molecules. 2016 Sep 28;21(10):1295. doi: 10.3390/molecules21101295.
The Pd-catalyzed direct alkylation of -phosphinic acids and hypophosphorous acid with allylic/benzylic alcohols has been described previously. Here, the extension of this methodology to -phosphinate esters is presented. The new reaction appears general, although its scope is narrower than with the acids, and its mechanism is likely different. Various alcohols are examined in their reaction with phosphinylidene compounds R¹R²P(O)H.
钯催化的次膦酸和次磷酸与烯丙基/苄醇的直接烷基化反应此前已有报道。在此，我们展示了该方法对次膦酸酯的拓展。新反应似乎具有通用性，尽管其适用范围比与酸反应时更窄，且其反应机理可能不同。研究了各种醇与亚膦酰基化合物R¹R²P(O)H的反应。
