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索氏小球藻提取物改善大鼠短期记忆。

Chlorella sorokiniana Extract Improves Short-Term Memory in Rats.

作者信息

Morgese Maria Grazia, Mhillaj Emanuela, Francavilla Matteo, Bove Maria, Morgano Lucia, Tucci Paolo, Trabace Luigia, Schiavone Stefania

机构信息

Department of Clinical and Experimental Medicine, University of Foggia, Foggia 71121, Italy.

Department of Physiology and Pharmacology, "Sapienza" University of Rome, Rome 00185, Italy.

出版信息

Molecules. 2016 Sep 29;21(10):1311. doi: 10.3390/molecules21101311.

Abstract

Increasing evidence shows that eukaryotic microalgae and, in particular, the green microalga , can be used as natural sources to obtain a whole variety of compounds, such as omega (ω)-3 and ω-6 polyunsatured fatty acids (PUFAs). Although either beneficial or toxic effects of have been mainly attributed to its specific ω-3 and ω-6 PUFAs content, the underlying molecular pathways remain to be elucidated yet. Here, we investigate the effects of an acute oral administration of a lipid extract of , containing mainly ω-3 and ω-6 PUFAs, on cognitive, emotional and social behaviour in rats, analysing possible underlying neurochemical alterations. Our results showed improved short-term memory in -treated rats compared to controls, without any differences in exploratory performance, locomotor activity, anxiety profile and depressive-like behaviour. On the other hand, while the social behaviour of -treated animals was significantly decreased, no effects on aggressivity were observed. Neurochemical investigations showed region-specific effects, consisting in an elevation of noradrenaline (NA) and serotonin (5-HT) content in hippocampus, but not in the prefrontal cortex and striatum. In conclusion, our results point towards a beneficial effect of extract on short-term memory, but also highlight the need of caution in the use of this natural supplement due to its possible masked toxic effects.

摘要

越来越多的证据表明,真核微藻,尤其是绿色微藻,可作为获取各种化合物的天然来源,如ω-3和ω-6多不饱和脂肪酸(PUFAs)。尽管其有益或毒性作用主要归因于其特定的ω-3和ω-6多不饱和脂肪酸含量,但其潜在的分子途径仍有待阐明。在此,我们研究了急性口服主要含有ω-3和ω-6多不饱和脂肪酸的脂质提取物对大鼠认知、情绪和社会行为的影响,并分析了可能的潜在神经化学变化。我们的结果显示,与对照组相比,经该提取物处理的大鼠短期记忆得到改善,在探索性能、运动活动、焦虑状态和抑郁样行为方面没有差异。另一方面,虽然经该提取物处理的动物的社会行为显著降低,但未观察到对攻击性的影响。神经化学研究显示了区域特异性效应,表现为海马中去甲肾上腺素(NA)和5-羟色胺(5-HT)含量升高,但前额叶皮质和纹状体中未升高。总之,我们的结果表明该提取物对短期记忆有有益作用,但也强调由于其可能存在的潜在毒性作用,在使用这种天然补充剂时需要谨慎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a39/6274193/083da0a4940f/molecules-21-01311-g001.jpg

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