Chagan-Yasutan Haorile, Chen Yue, Lacuesta Talitha Lea, Leano Prisca Susan A, Iwasaki Hiroko, Hanan Firmanto, Taurustiati Delsi, Ohmoto Yasukazu, Ashino Yugo, Saitoh Hiroki, Kiyomoto Hideyasu, Suzuki Yasuhiko, Telan Freda O Elizabeth, Hattori Toshio
Disaster-Related Infectious Disease, International Research Institute of Disaster Science, Tohoku University, 980-8575 Sendai, Japan.
Emerging Infectious Diseases, Department of Internal Medicine, Graduate School of Medicine, Tohoku University, 980-8575 Sendai, Japan.
Int J Mol Sci. 2016 Sep 27;17(10):1637. doi: 10.3390/ijms17101637.
Leptospirosis is a zoonotic disease whose severe forms are often accompanied by kidney dysfunction. In the present study, urinary markers were studied for potential prediction of disease severity. Urine samples from 135 patients with or without leptospirosis at San Lazaro Hospital, the Philippines, were analyzed. Urine levels of defensin α1 (uDA1) were compared with those of neutrophil gelatinase-associated lipocalin (uNGAL) and -acetyl-β-d-glucosidase (uNAG). Serum creatinine (Cr) was used as a marker of kidney injury. The levels of uDA1/Cr, uNGAL/Cr, and uNAG/Cr were positive in 46%, 90%, and 80% of leptospirosis patients, and 69%, 70%, and 70% of non-leptospirosis patients, respectively. In leptospirosis patients, the correlation of uDA1/Cr, uNGAL/Cr and uNAG/Cr levels with serum Cr were = 0.3 ( < 0.01), = 0.29 ( < 0.01), and = 0.02 ( = 0.81), respectively. uDA1/Cr levels were correlated with uNGAL/Cr levels ( = 0.49, < 0.01) and uNAG/Cr levels ( = 0.47, < 0.0001) in leptospirosis patients. These findings suggest that uDA1, uNGAL, and uNAG were elevated in leptospirosis patients and reflected various types of kidney damage. uDA1 and uNGAL can be used to track kidney injury in leptospirosis patients because of their correlation with the serum Cr level.
钩端螺旋体病是一种人畜共患疾病，其严重形式常伴有肾功能障碍。在本研究中，对尿液标志物进行了研究，以探讨其对疾病严重程度的潜在预测价值。分析了菲律宾圣拉萨罗医院135例有或无钩端螺旋体病患者的尿液样本。将防御素α1（uDA1）的尿液水平与中性粒细胞明胶酶相关脂质运载蛋白（uNGAL）和N-乙酰-β-D-葡萄糖苷酶（uNAG）进行比较。血清肌酐（Cr）用作肾损伤的标志物。钩端螺旋体病患者中uDA1/Cr、uNGAL/Cr和uNAG/Cr水平呈阳性的分别为46%、90%和80%，非钩端螺旋体病患者中分别为69%、70%和70%。在钩端螺旋体病患者中，uDA1/Cr、uNGAL/Cr和uNAG/Cr水平与血清Cr的相关性分别为r = 0.3（P < 0.01）、r = 0.29（P < 0.01）和r = 0.02（P = 0.81）。钩端螺旋体病患者中uDA1/Cr水平与uNGAL/Cr水平相关（r = 0.49，P < 0.01），与uNAG/Cr水平相关（r = 0.47，P < 0.0001）。这些发现表明，钩端螺旋体病患者中uDA1、uNGAL和uNAG升高，反映了不同类型的肾损伤。由于uDA1和uNGAL与血清Cr水平相关，因此可用于追踪钩端螺旋体病患者的肾损伤情况。
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