Universidad CES, Escuela de Graduados, Medellín, Antioquia, Colombia.
University of Minnesota, School of Public Health, Minneapolis, Minnesota, United States of America.
Rev Soc Bras Med Trop. 2023 Jan 23;56. doi: 10.1590/0037-8682-0260-2022. eCollection 2023.
Leptospirosis is a zoonotic infection with a global distribution, though it has a greater impact on marginalized rural agricultural and urban communities in developing countries. Kidney injury, which can lead to severe and lethal infections, is the most frequent complication associated with leptospirosis. Novel biomarkers are being studied as tools for assessing kidney injury in different pathological processes to improve early detection. This review aimed to gather information on the use of novel kidney biomarkers for human leptospirosis. A search of the literature was carried out in September 2021 using the parameters "((kidney) OR (renal) OR (chronic kidney disease) OR (acute kidney injury)) AND ((biomarker) OR (marker)) AND ((Leptospira) OR (leptospirosis))". The review identified 11 original studies that evaluated the performance of 15 kidney biomarkers related to leptospirosis. Assessment of the evidence for biomarker utility was limited because of the small number of studies and sample sizes. Although some biomarkers were associated with kidney disease, no specific biomarker appeared to be ready for clinical practice, and more research in this field is necessary.
钩端螺旋体病是一种具有全球分布的人畜共患病感染，尽管它对发展中国家边缘化的农村农业和城市社区的影响更大。肾脏损伤是与钩端螺旋体病相关的最常见并发症，可能导致严重和致命的感染。新型生物标志物正被研究作为评估不同病理过程中肾脏损伤的工具，以提高早期检测的效果。本综述旨在收集有关新型肾脏生物标志物在人类钩端螺旋体病中的应用信息。2021 年 9 月，使用“((kidney) OR (renal) OR (chronic kidney disease) OR (acute kidney injury)) AND ((biomarker) OR (marker)) AND ((Leptospira) OR (leptospirosis))”参数进行了文献检索。该综述共确定了 11 项原始研究，这些研究评估了与钩端螺旋体病相关的 15 种肾脏生物标志物的性能。由于研究数量和样本量较少，对生物标志物效用的证据评估受到限制。尽管一些生物标志物与肾脏疾病相关，但似乎没有一种特定的生物标志物可以用于临床实践，因此该领域需要进一步研究。
