Key Laboratory of Eco-textiles of Ministry of Education, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu 214122, China.
Carbohydr Polym. 2013 Jan 30;92(1):534-9. doi: 10.1016/j.carbpol.2012.08.115. Epub 2012 Sep 7.
The inherent antimicrobial properties and biodegradability of chitosan make it an ideal candidate for antimicrobial materials. In this study, N-halamine precursor 3-glycidyl-5,5-dimethylhydantoin (GH) was synthesized and bonded onto chitosan by a ring opening reaction between chitosan and GH. The chitosan film modified with the N-halamine precursor could be rendered biocidal after exposure to a dilute household bleach solution. Syntheses routes, characterization data, and antimicrobial test results are presented. The chlorinated films with 2.60 × 10(18) atoms/cm(2) of active chlorine were challenged with Staphylococcus aureus (ATCC 6538) and Escherichia coli O157:H7 (ATCC 43895) and showed good efficacy against these two bacterial species with log reductions of 7.4 and 7.5 within 10 and 5 min of contact time, respectively. These films may serve as potential materials for food packaging and biomedical applications.
壳聚糖具有内在的抗菌性能和生物降解性，使其成为抗菌材料的理想候选物。在这项研究中，通过壳聚糖和 GH 之间的开环反应，合成了 N-卤胺前体 3-缩水甘油基-5,5-二甲基海因（GH）并将其键合到壳聚糖上。壳聚糖膜经稀家用漂白剂溶液暴露后，可具有杀菌能力。本文介绍了合成路线、表征数据和抗菌测试结果。用 2.60×10(18)个原子/cm(2)的活性氯对氯代膜进行了挑战，分别用金黄色葡萄球菌（ATCC 6538）和大肠杆菌 O157:H7（ATCC 43895）进行了挑战，在 10 和 5 分钟的接触时间内，对这两种细菌的对数减少分别为 7.4 和 7.5。这些薄膜可用作食品包装和生物医学应用的潜在材料。
