18名儿童和50名成人吉兰-巴雷综合征的自然病史。
The natural history of the Guillain-Barré syndrome in 18 children and 50 adults.
作者信息
Kleyweg R P, van der Meché F G, Loonen M C, de Jonge J, Knip B
机构信息
Department of Neurology, University Hospital Dijkzigt, Rotterdam, The Netherlands.
出版信息
J Neurol Neurosurg Psychiatry. 1989 Jul;52(7):853-6. doi: 10.1136/jnnp.52.7.853.
Plasma exchange (PE) is indicated in adult patients with a severe Guillain-Barré syndrome (GBS). For children this has not been proven. If the disease runs a milder course in children, the problems experienced with PE might outweight the benefit. In order to evaluate the need for such a specific treatment in children, we compared the severity of the disease between 18 children and 50 adults; no significant differences were found. The mean duration of hospitalisation of all children was 84 days, four children needed artificial ventilation for a mean of 21.5 days and two children died. We conclude therefore that PE is indicated in children with a severe GBS. The final decision, however, depends also on the practical feasibility of the procedure.
血浆置换（PE）适用于患有严重吉兰-巴雷综合征（GBS）的成年患者。对于儿童而言，这一点尚未得到证实。如果该疾病在儿童中病程较为温和，那么血浆置换所带来的问题可能超过其益处。为了评估儿童是否需要这种特定治疗，我们比较了18名儿童和50名成人的疾病严重程度；未发现显著差异。所有儿童的平均住院时间为84天，4名儿童需要平均21.5天的人工通气，2名儿童死亡。因此，我们得出结论，血浆置换适用于患有严重GBS的儿童。然而，最终的决定还取决于该操作的实际可行性。
Zotero 插件