Winer J B, Hughes R A, Osmond C
Department of Neurology, United Medical School, Guy's Hospital, London, UK.
J Neurol Neurosurg Psychiatry. 1988 May;51(5):605-12. doi: 10.1136/jnnp.51.5.605.
A prospective study in South-East England during 15 months in 1983-1984 recruited 100 patients with acute idiopathic neuropathy. After 12 months 67% had recovered completely, 20% were still significantly disabled and 13% had died. Ten of the 13 deaths were attributable to the neuropathy. The major features in the initial assessment which were associated with persistent disability were the time taken to become bedbound, requirement for ventilation, age greater than 40 years, and small or absent compound abductor pollicis brevis muscle action potentials elicited by stimulation of the median nerve at the wrist. These four variables have been combined in a statistical model to predict outcome for individual patients with acute idiopathic neuropathy.
1983年至1984年期间，在英格兰东南部进行了一项为期15个月的前瞻性研究，招募了100例急性特发性神经病患者。12个月后，67%的患者完全康复，20%的患者仍有明显残疾，13%的患者死亡。13例死亡中有10例归因于神经病。初始评估中与持续残疾相关的主要特征是卧床时间、通气需求、年龄大于40岁，以及刺激腕部正中神经时引出的拇短展肌复合动作电位较小或消失。这四个变量已被纳入一个统计模型，以预测急性特发性神经病个体患者的预后。
