Ebmeier K P, Mutch W J, Calder S A, Crawford J R, Stewart L, Besson J O
Department of Mental Health, University of Aberdeen, UK.
J Neurol Neurosurg Psychiatry. 1989 Jul;52(7):911-3. doi: 10.1136/jnnp.52.7.911.
A study is presented which fails to replicate a recent report that peak years of birth of patients later developing Parkinson's disease are related to the influenza pandemics of the period 1890-1930. The years of birth of a whole population cohort of 243 patients suffering from Parkinson's disease examined in Aberdeen in 1983 and reexamined in 1986/7 were compared with deaths due to influenza in the City of Aberdeen in the years 1900-1930. Although a significant peak of Parkinson births (compared with the age profile of the Aberdeen population in 1983) occurred in 1902, there appeared to be no systematic relationship between Parkinson births and influenza deaths. In addition, no season of birth effect could be detected in a comparison with 232 matched controls. The presence of peaks of birth years, for whatever aetiological reason, is of significance to epidemiological studies in that prevalence estimates may be influenced by the year of study relative to these mini-cohorts.
一项研究表明，未能重复近期的一份报告，该报告称后来患帕金森病患者的出生高峰期与1890 - 1930年期间的流感大流行有关。对1983年在阿伯丁检查并于1986/7年重新检查的243名帕金森病患者的整个人口队列的出生年份，与1900 - 1930年阿伯丁市因流感死亡的情况进行了比较。尽管1902年出现了帕金森病患者出生的显著高峰（与1983年阿伯丁人口的年龄分布相比），但帕金森病患者出生与流感死亡之间似乎没有系统的关系。此外，与232名匹配对照进行比较时，未检测到出生季节效应。无论病因如何，出生年份高峰的存在对流行病学研究具有重要意义，因为患病率估计可能会受到相对于这些小队列的研究年份的影响。
