Mattock C, Marmot M, Stern G
Department of Community Medicine, University College and Middlesex School of Medicine, London, UK.
J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):753-6. doi: 10.1136/jnnp.51.6.753.
Patients with idiopathic Parkinson's disease do not appear to be distributed smoothly with respect to year of birth. Individuals born within the years 1892, 1904, 1909, 1918, 1919 and 1929 appear to have had an increased risk of developing idiopathic Parkinson's disease in later life. These years are close to those of the influenza pandemics of the period 1890-1930. The estimated risk of an individual developing idiopathic Parkinson's disease shows a significant correlation with the crude influenza mortality for the year of his birth, within the range 1900 to 1930. It is suggested that intra-uterine influenza may be cytotoxic to the developing foetal substantia nigra, and that an affected individual may be born without evident disability but with limited striatal neurochemical reserves and a reduced nigral cell count. In later life normal cellular involution with ageing or exposure to environmental neurotoxic factors may further erode these reserves to a level where the substantia nigra fails and idiopathic Parkinson's disease becomes clinically apparent.
特发性帕金森病患者的出生年份分布似乎并不均匀。出生于1892年、1904年、1909年、1918年、1919年和1929年的个体，在晚年患特发性帕金森病的风险似乎有所增加。这些年份与1890 - 1930年期间的流感大流行年份相近。在1900年至1930年范围内，个体患特发性帕金森病的估计风险与他出生年份的流感粗死亡率呈显著相关性。有人提出，子宫内感染流感可能对发育中的胎儿黑质具有细胞毒性，受影响的个体出生时可能没有明显残疾，但纹状体神经化学储备有限且黑质细胞数量减少。在晚年，随着年龄增长的正常细胞退化或接触环境神经毒性因素可能会进一步消耗这些储备，直至黑质功能衰竭，特发性帕金森病在临床上显现出来。
