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婴幼儿缩窄性主动脉弓重建的结局:手术入路的重要性。

Outcome of aortic arch reconstruction in infants with coarctation: Importance of operative approach.

机构信息

Department of Pediatric Cardiology, Children's Heart Center Linz, Kepler University Clinic, Linz, Austria.

Department of Pediatric Cardiac Surgery, Children's Heart Center Linz, Kepler University Clinic, Linz, Austria.

出版信息

J Thorac Cardiovasc Surg. 2016 Dec;152(6):1506-1513.e1. doi: 10.1016/j.jtcvs.2016.08.029. Epub 2016 Aug 31.

Abstract

OBJECTIVES

Coarctation with hypoplastic aortic arch can be treated with resection and extended end-to-end anastomosis (REEEA) as well as end-to-side anastomosis (ESA). The aim of the study was to review our experience with these techniques in newborns and infants and to assess mid-term outcome with regards to morbidity, mortality, and reintervention rate in relation to operative access and technique.

PATIENTS AND METHODS

Retrospective review of hospital charts and surgical reports from 183 consecutive newborns and infants with coarctation and hypoplastic aortic arch with or without ventricular septal defect between 1996 and 2013. Median age at surgery was 15 days (0-345). Lateral thoracotomy was used as operative access in 111 patients; 72 patients had a median sternotomy, 71 of them with cardiopulmonary bypass (ESA n = 30, REEEA n = 41). Fifty-two patients (28.4%) had an additional ventricular septal defect closure. Follow-up data were available for 75.96% with a median follow-up of 6.3 years (0.2-18.16 years).

RESULTS

Thirty-day mortality was 0.54% with no late mortality occurring during follow-up. There was 1 severe complication: paraplegia and cerebral hypoxemia after REEEA. Freedom from mortality and reintervention at 10 years was 99.27% and 90.12%, respectively. Lateral thoracotomy as operative access was a risk factor for recurrent obstruction (P = .03).

CONCLUSIONS

REEEA and ESA were safe and effective treatments in newborns and infants. In borderline cases, aortic arch reconstruction should be performed through a median sternotomy on bypass.

摘要

目的

伴有主动脉弓发育不良的缩窄可以通过切除和端对端吻合(REEEA)以及端侧吻合(ESA)进行治疗。本研究旨在回顾我们在新生儿和婴儿中应用这些技术的经验,并评估与手术入路和技术相关的发病率、死亡率和再干预率的中期结果。

患者和方法

回顾性分析 1996 年至 2013 年间 183 例连续患有缩窄伴主动脉弓发育不良和/或室间隔缺损的新生儿和婴儿的病历和手术报告。手术时的中位年龄为 15 天(0-345 天)。111 例患者采用侧胸切口作为手术入路;72 例患者采用正中胸骨切开术,其中 71 例患者采用体外循环(ESA 组 n=30,REEEA 组 n=41)。52 例(28.4%)患者同时行室间隔缺损修补术。75.96%的患者获得随访资料,中位随访时间为 6.3 年(0.2-18.16 年)。

结果

30 天死亡率为 0.54%,随访期间无晚期死亡。有 1 例严重并发症:REEEA 后截瘫和脑缺氧。10 年无死亡率和再干预率分别为 99.27%和 90.12%。侧胸切口作为手术入路是再梗阻的危险因素(P=0.03)。

结论

REEEA 和 ESA 是新生儿和婴儿安全有效的治疗方法。在临界病例中,应通过体外循环的正中胸骨切开术进行主动脉弓重建。

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