Jones Buie Joy N, Goodwin Andrew J, Cook James A, Halushka Perry V, Fan Hongkuan
Medical University of South Carolina, Department of Pathology and Laboratory Medicine, 173 Ashley Avenue, Suite CRI 605B, Charleston, United States.
Medical University of South Carolina, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Charleston, United States.
Atherosclerosis. 2016 Nov;254:271-281. doi: 10.1016/j.atherosclerosis.2016.09.067. Epub 2016 Sep 22.
Coronary artery disease and atherosclerosis are complex pathologies that develop over time due to genetic and environmental factors. Differential expression of miRNAs has been identified in patients with coronary artery disease and atherosclerosis, however, their association with cardiovascular disease risk factors, including hyperlipidemia, hypertension, obesity, diabetes, lack of physical activity and smoking, remains unclear. This review examines the role of miRNAs as either biomarkers or potential contributors to the pathophysiology of these aforementioned risk factors. It is intended to provide an overview of the published literature which describes alterations in miRNA levels in both human and animal studies of cardiovascular risk factors and when known, the possible mechanism by which these miRNAs may exert either beneficial or deleterious effects. The intent of this review is engage clinical, translational, and basic scientists to design future collaborative studies to further elucidate the potential role of miRNAs in cardiovascular diseases.
冠状动脉疾病和动脉粥样硬化是复杂的病理状况，随着时间的推移，由于遗传和环境因素而发展。在冠状动脉疾病和动脉粥样硬化患者中已发现微小RNA（miRNA）的差异表达，然而，它们与心血管疾病风险因素（包括高脂血症、高血压、肥胖、糖尿病、缺乏体育活动和吸烟）之间的关联仍不清楚。本综述探讨了miRNA作为生物标志物或上述风险因素病理生理学潜在促成因素的作用。其目的是提供已发表文献的概述，这些文献描述了在人类和动物心血管风险因素研究中miRNA水平的变化，以及在已知情况下，这些miRNA可能发挥有益或有害作用的可能机制。本综述的目的是促使临床、转化和基础科学家设计未来的合作研究，以进一步阐明miRNA在心血管疾病中的潜在作用。
