Zhou Ling, Wan Baoquan, Liu Xingfa, Zhang Yemao, Lai Jinsheng, Ruan Guoran, He Mengying, Chen Chen, Wang Dao Wen
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Avenue, Wuhan, 430030, China.
State Key Laboratory of Power Grid Environmental Protection, China Electric Power Research Institute, Wuhan, 430074, China.
J Radiat Res. 2016 Nov;57(6):627-636. doi: 10.1093/jrr/rrw090. Epub 2016 Sep 21.
A 50-Hz magnetic field (MF) is a potential health-risk factor. Its effects on the cardiovascular system have not been fully investigated. This study was conducted to explore the effects of long-term exposure to a 50-Hz MF on the cardiovascular system. In the study, an exposure system was constructed, and the distribution of the 50-Hz MF was determined. Sixty-four Sprague-Dawley (SD) rats were exposed to a 50-Hz MF at 100 μT for 24 weeks, 20 h per day, while another 64 rats were sham exposed. During the exposure, blood pressure was measured every 4 weeks. After 24 weeks, echocardiography, cardiac catheterization and electrocardiography were performed. Moreover, heart and body weight were recorded, and haematoxylin-eosin staining and real-time PCR were conducted. The results showed that compared with the sham group, exposure to a 50-Hz MF did not exert any effects on blood pressure, pulse rate, heart rate or cardiac rhythm. Furthermore, echocardiography and cardiac catheterization showed that there were no significant differences in the cardiac morphology or haemodynamics. In addition, histopathological examination showed that exposure to a 50-Hz MF had no effects on the structure of the heart. Finally, expression of the cardiac hypertrophy-related genes did not show any significant differences between the 50-Hz MF exposure group and the sham group. Taken together, in SD rats, exposure to a 50-Hz/100 μT MF for 24 weeks did not show any obvious effects on the cardiovascular system.
50赫兹的磁场（MF）是一个潜在的健康风险因素。其对心血管系统的影响尚未得到充分研究。本研究旨在探讨长期暴露于50赫兹磁场对心血管系统的影响。在该研究中，构建了一个暴露系统，并测定了50赫兹磁场的分布。64只斯普拉格-道利（SD）大鼠每天20小时暴露于100微特斯拉的50赫兹磁场中，持续24周，而另外64只大鼠进行假暴露。在暴露期间，每4周测量一次血压。24周后，进行了超声心动图、心导管检查和心电图检查。此外，记录了心脏和体重，并进行了苏木精-伊红染色和实时聚合酶链反应。结果表明，与假暴露组相比，暴露于50赫兹磁场对血压、脉搏率、心率或心律没有任何影响。此外，超声心动图和心导管检查显示，心脏形态或血流动力学没有显著差异。此外，组织病理学检查表明，暴露于50赫兹磁场对心脏结构没有影响。最后，心脏肥大相关基因的表达在50赫兹磁场暴露组和假暴露组之间没有显示出任何显著差异。综上所述，在SD大鼠中，暴露于50赫兹/100微特斯拉磁场24周对心血管系统没有显示出任何明显影响。
