National Institute of Health and Medical Research (INSERM) U1297, CEDEX 4, 31432 Toulouse, France.
University Toulouse III, 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France.
Int J Mol Sci. 2023 Jul 20;24(14):11709. doi: 10.3390/ijms241411709.
Environmental stress can disturb the integrative functioning of the cardiovascular system and trigger a number of adaptive and/or maladaptive cell responses. Concomitant with the expanding use of mobile communication systems, public exposure to electromagnetic fields (EMFs) raises the question of the impact of 900 MHz EMFs on cardiovascular health. Therefore, in this study, we experimentally investigated whether 915 MHz EMF exposure influenced cardiac metabolic, antioxidant, apoptotic, and fibro-inflammatory profiles in a mouse model. Healthy mice were sham-exposed or exposed to EMF for 14 days. Western blot analysis using whole cardiac tissue lysates demonstrated that there was no significant change in the expression of oxidative phosphorylation (OXPHOS) complexes between the control and EMF-exposed mice. In addition, the myocardial expression of fibro-inflammatory cytokines, antioxidant enzymes, and apoptosis-related markers remained unchanged in the EMF-challenged hearts. Finally, the structural integrity of the cardiac tissues was preserved among the groups. These findings suggest that the apoptotic, antioxidant, metabolic, and fibro-inflammatory profiles of the heart remained stable under conditions of EMF exposure in the analyzed mice.
环境压力会干扰心血管系统的整体功能，并引发一系列适应性和/或不适应性的细胞反应。随着移动通信系统的广泛应用，公众接触电磁场（EMF）引发了一个问题，即 900MHz EMF 是否会对心血管健康产生影响。因此，在这项研究中，我们在小鼠模型中实验性地研究了 915MHz EMF 暴露是否会影响心脏代谢、抗氧化、凋亡和纤维炎症特征。健康小鼠进行假暴露或 EMF 暴露 14 天。使用整个心脏组织裂解物进行的 Western blot 分析表明，对照组和 EMF 暴露组小鼠之间氧化磷酸化（OXPHOS）复合物的表达没有显著变化。此外，在 EMF 挑战的心脏中，纤维炎症细胞因子、抗氧化酶和凋亡相关标志物的心肌表达保持不变。最后，各组的心脏组织结构完整性得以保留。这些发现表明，在分析的小鼠中，EMF 暴露条件下心脏的凋亡、抗氧化、代谢和纤维炎症特征保持稳定。
