宫颈阴道炎症促进感染性较低的HIV变体的获得。
Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.
作者信息
Selhorst Philippe, Masson Lindi, Ismail Sherazaan D, Samsunder Natasha, Garrett Nigel, Mansoor Leila E, Abdool Karim Quarraisha, Abdool Karim Salim S, Passmore Jo-Ann S, Williamson Carolyn
机构信息
Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
出版信息
Clin Infect Dis. 2017 Jan 1;64(1):79-82. doi: 10.1093/cid/ciw663. Epub 2016 Sep 29.
Abstract
We evaluated whether genital inflammation affects the selection of the transmitted virus. Among South African women, we found that preinfection genital inflammation facilitates transmission of less infectious human immunodeficiency virus, but highly infectious viruses are able to establish infection regardless of inflammation status. This suggests that viral phenotype can influence transmission risk.
摘要
我们评估了生殖器炎症是否会影响传播病毒的选择。在南非女性中，我们发现感染前的生殖器炎症会促进传染性较低的人类免疫缺陷病毒的传播，但高传染性病毒无论炎症状态如何都能够建立感染。这表明病毒表型可能会影响传播风险。
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