Hayman J A, Danks J A, Ebeling P R, Moseley J M, Kemp B E, Martin T J
University of Melbourne Department of Pathology, Victoria, Australia.
J Pathol. 1989 Aug;158(4):293-6. doi: 10.1002/path.1711580405.
Parathyroid hormone related protein (PTHrP) has been demonstrated in the tumour cells of squamous cell carcinomas originating in a variety of organs, in undifferentiated small cell tumours of the bronchus, and in carcinoma of the kidney. The protein hormone is thought to produce the hypercalcaemia which may complicate some of these malignancies. By using an antibody raised in rabbits against the N-terminal portion of the molecule, the polypeptide may be demonstrated in cells of the prickle cell layer of normal skin and in the cells of hair follicles. Skin tumours showing squamous or hair follicle differentiation are shown to contain the protein antigen, while basal cell carcinomas and tumours with sweat gland differentiation do not. The hormone may be primordial in origin and the progenitor of parathyroid hormone.
甲状旁腺激素相关蛋白（PTHrP）已在源自各种器官的鳞状细胞癌的肿瘤细胞、支气管未分化小细胞肿瘤以及肾癌中得到证实。这种蛋白质激素被认为会导致高钙血症，而高钙血症可能会使其中一些恶性肿瘤病情复杂化。通过使用针对该分子N端部分产生的兔抗体，可在正常皮肤棘细胞层的细胞和毛囊细胞中检测到这种多肽。显示有鳞状或毛囊分化的皮肤肿瘤含有该蛋白质抗原，而基底细胞癌和有汗腺分化的肿瘤则不含。这种激素可能起源于原始状态，是甲状旁腺激素的前身。
